Results 51 to 60 of about 269,095 (265)
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
THERMAL EFFECT ANALYSIS OF ROLLING FRICTION IN HIGH SPEED COLD ROLL-BEATING FORMING
Jixie qiangdu, 2018 High-speed cold forming is a complex forming process coupling under multi factors, which has the rolling friction affecting the fluidity of the workpiece metal, and then affecting the quality and performance of the forming parts.
LI YuXi +4 more
doaj
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
MetalsThe present research investigates the optimization of the punching process in cold forming manufacturing, focusing on enhancing tool life, reducing damage, and improving product quality.
Abdelwaheb Zeidi +3 more
doaj +1 more source
Influence of surface integrity on the plastic flow in analogous testing of 42CrMo4
MATEC Web of Conferences, 2018 Surface modification of workpieces for cold forming processes is common in industrial practice. Specific surface topographies manufactured by means of shot peening form lubricant pockets, which provide a continuous lubricating film throughout the process.
Hild Rafael +7 more
doaj +1 more source
Molecular Oncology, EarlyView.Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant +11 more
wiley +1 more source
Taiyuan Ligong Daxue xuebao【Purposes】To investigate the residual stress distribution patterns in high-strength welded circular steel tubes, the hole-drilling strain-gage method is used to measure the surface residual stresses of two Q460C circular steel tube specimens with ...
ZHAI Xiang +5 more
doaj +1 more source
Reducing Abrasive Particle Generation in Dry Rotary Swaging by Utilizing DLC Hard Coated Dies
MATEC Web of Conferences, 2018 The emphasis of this paper is the investigation of the impact of the diamond like carbon (DLC) hard coating system on the amount of abrasive particles being generated during dry rotary swaging.
Böhmermann Florian +3 more
doaj +1 more source