Results 51 to 60 of about 1,899,113 (252)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Determination of 40Cr Johnson–Cook Dynamic Constitutive Equation for Cold roll-beating Forming Process

Chemical Engineering Transactions, 2015
As a near net-shape advanced manufacturing technology, cold roll-beating is a dieless unconstrained incremental forming technology. For the features of the forming process, it is necessary to study the forming mechanism under thermal–mechanical coupling ...
Y.X. Li, Y. Li, M.S. Yang, F.Z. Wei, Q.L. Yuan, F.K. Cui   +5 more
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Process chain for the fabrication of hardenable aluminium-zirconium micro-components by deep drawing

MATEC Web of Conferences, 2018
Today, micro components are used in various industrial sectors such as electronics engineering and medical applications. The final quality of such parts depends on each individual step of the production chain from the manufacturing of semi-finished parts
Toenjes Anastasiya, Kovac Julien, Koehler Bernd, von Hehl Axel, Mehner Andreas, Clausen Brigitte, Zoch Hans-Werner   +6 more
doaj   +1 more source

Comparison between incremental deformation theory and flow rule to simulate sheet-metal forming processes [PDF]

, 2012
Numerical simulation of the deep drawing process for the manufacture of aeronautical or automotive components should predict with good accuracy the behaviour during the forming operation, taking into account, the material and the process parameters ...
BATOZ, Jean-Louis, DAL SANTO, Philippe, DELAMEZIERE, Arnaud, ROBERT, Camille   +3 more
core  

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Microstructure Evolution and Material Flow of Steel in Semi-solid Forming Process [PDF]

, 2011
The present study aims to identify and characterize the development of microstructure and deformation characteristics of steel grades in semi-solid state which is affected by the change in morphologies of microstructure at high temperature ...
GU, Guochao, LANGLOIS, Laurent, BECKER, Eric, PESCI, Raphaël, BIGOT, Régis   +4 more
core  

Investigation of tribological properties of AlMg4,5Mn0,7 in a warm forming process using the barrel compression test

, 2022
S.633-638Within the German Collaborative Research Center 39 PT-PIESA the forming of micro cavities into aluminum sheets is one challenging task. During this forming process high forces and stresses occur which lead to a high tool wear.
Müller, B., Fang, R., Jahn, S.F., Schubert, A.   +3 more
core   +1 more source