Results 51 to 60 of about 280,496 (307)
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
Düzce Üniversitesi Bilim ve Teknoloji Dergisi, 2018 Civataüretiminin kritik prosesi olan ısıl işlem prosesi; soğuk şekillendirilenmalzemenin metalografik ve mekanik özelliklere olan etkisinin araştırılması,hem proses verimi hemde ürün performans kriterleri açısındandeğerlendirildiğinde sektörde deneysel ...
ALPER Baygut +2 more
doaj +1 more source
Micromachines, 2021 Compared to alternative production methods, cold forming offers technological, economic and ecological potential for the mass production of microgears.
Andreas Rohrmoser +2 more
doaj +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Correlating Ultrasonic Velocity in DC04 with Microstructure for Quantification of Ductile Damage
Journal of Manufacturing and Materials Processing, 2023 The detection of ductile damage by image-based methods is time-consuming and typically probes only small areas. It is therefore of great interest for various cold forming processes, such as sheet-bulk metal forming, to develop new methods that can be ...
Steffen Wackenrohr +4 more
doaj +1 more source
Temperature supported forming operations of lightweight materials
, 2022 S.263-266Due to the requirements to reduce the part weights in automotive manufacuring significantly, the use of lightweight materials such as aluminium, magnesium and high-strength steels becomes more and more important.
Sterzing, A. +2 more
core
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
An Experimental and Analytical Method for Investigating Plastic Flow in Form Tapping [PDF]
, 2006 While threaded holes made by cutting taps result in material removal, in form tapping, the tap displaces the work material by plastic flow to form the thread section.
FROMENTIN, Guillaume +2 more
core
Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source