Results 31 to 40 of about 1,899,113 (252)
Scientific Reports, 2022 Cold rolling has detrimental effect on the formability of sheet metals. It is, however, inevitable in producing sheet high quality surfaces. The effects of cold rolling on the forming limits of stretch sheets are not investigated comprehensively in the ...
Yichen Xie +4 more
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Ecological lubrication in cold forming of sintered powder metallurgical components [PDF]
, 2018 In this contribution a new lubrication approach for cold bulk metal forming is presented. By exploiting the process-related porosity of pm components as a lubricant storage, the resulting pressure of a forming process forces the stored oil to leak out ...
Behrens, Bernd-Arno
core +1 more source
Influence of Organo-Sulfur Compounds with Overbased Calcium Compounds on Lubrication in Cold Forming
Lubricants, 2017 The authors analyzed the structures of sulfurized olefins using NMR spectroscopy and studied the effects of sulfur chain length and alkyl structure on the ironing performance.
Tomohiro Takaki +3 more
doaj +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Analysis of Forming Behavior in Cold Forging of AISI 1010 Steel Using Artificial Neural Network
, 2020 Cold forged parts are mainly employed in automotive and aerospace assemblies, and strength plays an essential role in such applications. Backward extrusion is one such process in cold forging for the production of axisymmetrical cup-like parts, which is ...
J. Paulo Davim +5 more
core +1 more source
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
MATEC Web of Conferences, 2018 In order to reduce friction and wear in cold forging of aluminium and its alloys a tremendous amount of lubricants is used. The main task of the liquid lubricants is the separation of tool and workpiece surfaces to avoid adhesion and abrasion.
Teller Marco +7 more
doaj +1 more source