Results 71 to 80 of about 1,899,113 (252)

Modelling hot (metal) sheet forming with cold tooling

open access: yes, 2012
Use of cold tooling is beneficial in the sheet metal forming. This paper presents simulations of the process with the objective of investigating issues associated with thermal management, and of providing thermo-mechanical data for future ...
Spence, Julian   +4 more
core  

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim   +17 more
wiley   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

open access: yesMolecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba   +5 more
wiley   +1 more source

Innovative cold joining technologies based on tube forming

open access: yesManufacturing Review, 2015
This paper is focused on innovative cold joining technologies for connecting tubes and fixing tubes to sheets. The proposed technologies are based on the utilization of plastic instability waves in thin-walled tubes subjected to axial compression and may
Alves Luis M.   +2 more
doaj   +2 more sources

Finite Element Modelling of Cold Formed Stainless Steel Columns

open access: yesActa Polytechnica, 2005
This paper describes the results obtained from a finite element investigation into the load capacity of column members of lipped channel cross-section, cold formed from Type 304 stainless steel, subjected to concentric and eccentric compression loading ...
M. Macdonald, J. Rhodes
doaj  

Optimizing Stainless Steel Bearings: Enhancement of Stainless Steel Bearing Fatigue Life by Low-Temperature Forming

open access: yesMetals
A proposed low-temperature forging method is presented to enhance stainless steel bearings by creating a martensitic subsurface layer, significantly boosting bearing fatigue life due to increased surface hardness.
Alexander Heinrich Bodewig   +2 more
doaj   +1 more source

Material flow control in sheet-bulk metal forming processes using blasted tool surfaces

open access: yesMATEC Web of Conferences, 2018
Highly-integrated and closely-tolerated functional components can be produced by sheet-bulk metal forming which is the application of bulk forming operations on sheet metals.
Merklein Marion   +3 more
doaj   +1 more source

Automation of choosing technologies of cold massive forming

open access: yesВестник СибАДИ, 2017
The authors suggest to use the tables of possible variants, which contain the schemes of forming primary blanks and semi-finished products for subsequent operations and mathematical models to determine the optimal combination of number of stamping’s ...
I. I. Zavyalov   +3 more
doaj   +1 more source

An Experimental and Analytical Method for Investigating Plastic Flow in Form Tapping [PDF]

open access: yes, 2006
While threaded holes made by cutting taps result in material removal, in form tapping, the tap displaces the work material by plastic flow to form the thread section.
FROMENTIN, Guillaume   +2 more
core  

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

open access: yesFEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose   +9 more
wiley   +1 more source

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