Results 71 to 80 of about 280,496 (307)
Process chain for the fabrication of hardenable aluminium-zirconium micro-components by deep drawing
MATEC Web of Conferences, 2018 Today, micro components are used in various industrial sectors such as electronics engineering and medical applications. The final quality of such parts depends on each individual step of the production chain from the manufacturing of semi-finished parts
Toenjes Anastasiya +6 more
doaj +1 more source
Análise do processo de estampagem de chapas de aço através da curva limite de conformação [PDF]
, 2012 Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro Tecnológico, Programa de Pós-Graduação em Ciência e Engenharia de Materiais, Florianópolis, 2009O presente trabalho teve como objetivo aplicar na indústria de eletrodomésticos da ...
Bastos, Alexandre Lundgren
core
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
THERMAL EFFECT ANALYSIS OF ROLLING FRICTION IN HIGH SPEED COLD ROLL-BEATING FORMING
Jixie qiangdu, 2018 High-speed cold forming is a complex forming process coupling under multi factors, which has the rolling friction affecting the fluidity of the workpiece metal, and then affecting the quality and performance of the forming parts.
LI YuXi +4 more
doaj
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
Modelling hot (metal) sheet forming with cold tooling
, 2012 Use of cold tooling is beneficial in the sheet metal forming. This paper presents simulations of the process with the objective of investigating issues associated with thermal management, and of providing thermo-mechanical data for future ...
Spence, Julian +4 more
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Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Influence of surface integrity on the plastic flow in analogous testing of 42CrMo4
MATEC Web of Conferences, 2018 Surface modification of workpieces for cold forming processes is common in industrial practice. Specific surface topographies manufactured by means of shot peening form lubricant pockets, which provide a continuous lubricating film throughout the process.
Hild Rafael +7 more
doaj +1 more source
Cailiao gongcheng, 2020 Effect of different cold rolling deformations before intermediate annealing on the microstructure and forming properties of 6A16 aluminum alloy sheet during subsequent processing was investigated by means of EBSD and mechanical properties tests.The ...
YAN Li-zhen +5 more
doaj +1 more source