Results 81 to 90 of about 280,496 (307)
, 2022 S.473-479In cold extrusion of aluminum alloys adhesive wear can be prevented by an excessive lubrication of the process. While this causes additional process steps also environmental risks have to be addressed. Hence, dry metal forming, i.e.
Bolvardi, H. +8 more
core +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Reducing Abrasive Particle Generation in Dry Rotary Swaging by Utilizing DLC Hard Coated Dies
MATEC Web of Conferences, 2018 The emphasis of this paper is the investigation of the impact of the diamond like carbon (DLC) hard coating system on the amount of abrasive particles being generated during dry rotary swaging.
Böhmermann Florian +3 more
doaj +1 more source
, 2000 Cold formed products are increasingly serving as high duty machine parts. Designers and users need to know their properties as accurate as possible. One such product property is the new yield stress, which can be approximated by the final flow stress of ...
Tekkaya, AE
core
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Innovative cold joining technologies based on tube forming
Manufacturing Review, 2015 This paper is focused on innovative cold joining technologies for connecting tubes and fixing tubes to sheets. The proposed technologies are based on the utilization of plastic instability waves in thin-walled tubes subjected to axial compression and may
Alves Luis M. +2 more
doaj +2 more sources
Effect of Natural Aging on Cold Forming Performance of 2219 Aluminum Alloy. [PDF]
Materials (Basel), 2023 Li ZX, Shi YL, Xu LP, Jin JX.
europepmc +1 more source
Material flow control in sheet-bulk metal forming processes using blasted tool surfaces
MATEC Web of Conferences, 2018 Highly-integrated and closely-tolerated functional components can be produced by sheet-bulk metal forming which is the application of bulk forming operations on sheet metals.
Merklein Marion +3 more
doaj +1 more source
Automation of choosing technologies of cold massive forming
Вестник СибАДИ, 2017 The authors suggest to use the tables of possible variants, which contain the schemes of forming primary blanks and semi-finished products for subsequent operations and mathematical models to determine the optimal combination of number of stamping’s ...
I. I. Zavyalov +3 more
doaj +1 more source