Results 61 to 70 of about 1,899,113 (252)
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
THERMAL EFFECT ANALYSIS OF ROLLING FRICTION IN HIGH SPEED COLD ROLL-BEATING FORMING
Jixie qiangdu, 2018 High-speed cold forming is a complex forming process coupling under multi factors, which has the rolling friction affecting the fluidity of the workpiece metal, and then affecting the quality and performance of the forming parts.
LI YuXi +4 more
doaj
Molecular Oncology, EarlyView.Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani +9 more
wiley +1 more source
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source
MetalsThe present research investigates the optimization of the punching process in cold forming manufacturing, focusing on enhancing tool life, reducing damage, and improving product quality.
Abdelwaheb Zeidi +3 more
doaj +1 more source
Influence of surface integrity on the plastic flow in analogous testing of 42CrMo4
MATEC Web of Conferences, 2018 Surface modification of workpieces for cold forming processes is common in industrial practice. Specific surface topographies manufactured by means of shot peening form lubricant pockets, which provide a continuous lubricating film throughout the process.
Hild Rafael +7 more
doaj +1 more source
Effects of Vibrations on Metal Forming Process: Analytical Approach and Finite Element Simulations [PDF]
, 2010 Vibration assisted forming is one of the most recent and beneficial technique used to improve forming process. Effects of vibration on metal forming processes can be attributed to two causes.
ABBA, Gabriel +3 more
core
Molecular Oncology, EarlyView.We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth +17 more
wiley +1 more source
Taiyuan Ligong Daxue xuebao【Purposes】To investigate the residual stress distribution patterns in high-strength welded circular steel tubes, the hole-drilling strain-gage method is used to measure the surface residual stresses of two Q460C circular steel tube specimens with ...
ZHAI Xiang +5 more
doaj +1 more source
Reducing Abrasive Particle Generation in Dry Rotary Swaging by Utilizing DLC Hard Coated Dies
MATEC Web of Conferences, 2018 The emphasis of this paper is the investigation of the impact of the diamond like carbon (DLC) hard coating system on the amount of abrasive particles being generated during dry rotary swaging.
Böhmermann Florian +3 more
doaj +1 more source