Results 61 to 70 of about 280,496 (307)
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
Chemical Engineering Transactions, 2015 As a near net-shape advanced manufacturing technology, cold roll-beating is a dieless unconstrained incremental forming technology. For the features of the forming process, it is necessary to study the forming mechanism under thermal–mechanical coupling ...
Y.X. Li +5 more
doaj +1 more source
, 2006 Largely applied to internal threading of extruded tubes, cold form tapping is now becoming a promising process for internal threading of holes in non ferrous and ferrous solid components, more particularly for mass production in the automotive industry ...
JULIEN, Benoit +4 more
core
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
MetalsThe present research investigates the optimization of the punching process in cold forming manufacturing, focusing on enhancing tool life, reducing damage, and improving product quality.
Abdelwaheb Zeidi +3 more
doaj +1 more source
Dimpling process in cold roll metal forming by finite element modelling and experimental validation
, 2014 The dimpling process is a novel cold-roll forming process that involves dimpling of a rolled flat strip prior to the roll forming operation. This is a process undertaken to enhance the material properties and subsequent products’ structural performance ...
Nguyen, Van Bac +9 more
core +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Single point incremental forming of cold-rolled polycarbonate sheets
, 2019 The present work aims to examine the influence of a preliminary cold-rolling of polycarbonate sheets on the single point incremental forming of this outstanding engineering material.
Langella, A. +9 more
core +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source