Results 101 to 110 of about 1,125,979 (313)

Modifications of Gait as Predictors of Natural Osteoarthritis Progression in STR/Ort Mice [PDF]

, 2014
Objective. Osteoarthritis (OA) is a common chronic disease for which disease-modifying therapies are not currently available. Studies to seek new targets for slowing the progress of OA rely on mouse models, but these do not allow for longitudinal ...
Poulet, B, De Souza, R, Knights, C B, Gentry, C, Wilson, A M, Bevan, S, Chang, Y M, Pitsillides, A A, Fed Mato Grosso, King's, UCL   +10 more
core   +5 more sources

Buck Wheat: Nutritional, Bioactive Characteristics, Health Benefits, and Side Effects

Future Postharvest and Food, EarlyView.
ABSTRACT Micronutrient deficits have resulted from an over‐reliance on a small number of cereal crops for food security. The agricultural sector faces severe sustainability issues due to the rapid growth of the world's population and sudden climatic changes.
Momina Farooq, Sajad Ahmad Mir, Zahida Naseem   +2 more
wiley   +1 more source

Cold pain hypersensitivity predicts trajectories of pain and disability after low back surgery: a prospective cohort study.

Pain, 2020
Improving the ability to predict persistent pain after spine surgery would allow identification of patients at risk and guide treatment decisions.
Monika Müller, Lukas Bütikofer, O. K. Andersen, P. Heini, L. Arendt-Nielsen, P. Jüni, M. Curatolo   +6 more
semanticscholar   +1 more source

Effectiveness of desensitizing dentifrice and mouthwash on dentin hypersensitivity and tooth remineralization

Contemporary Clinical Dentistry, 2018
Background: Over many years, numerous products have been suggested for the relief of dentin hypersensitivity (DH). Calcium sodium phosphosilicate is one desensitizing agent that has remineralizing potential. Available in toothpaste and mouthwash delivery
Shweta Sharda, Kakarlap V. V. Prasad, Preetha J Shetty, Krithi Nikhil   +3 more
doaj   +1 more source

Mechanisms of spinal glial activation in chemotherapy‐induced peripheral neuropathy: Focus on microglia and astrocytes

Ibrain, EarlyView.
Chemotherapy‐induced peripheral neuropathy (CIPN) remains a major clinical challenge, with central sensitization considered an important pathological mechanism in its occurrence and persistence. This review focuses on spinal astrocytes and microglia, systematically summarizing the pathological mechanisms of spinal glial cells involved in CIPN caused by
Long Gu, Song Cao, Yonghuai Feng
wiley   +1 more source

Short-chain fatty acid, butyrate prevents morphine-and paclitaxel-induced nociceptive hypersensitivity

Scientific Reports, 2023
Nociceptive hypersensitivity is a significant side effect with the chronic administration of opioids as well as chemotherapeutics. Both opioid-induced hypersensitivity (OIH) and chemotherapy-induced hypersensitivity (CIH) are characterized by an ...
Dawn Jessup, Kareem Woods, Sach Thakker, M. Imad Damaj, Hamid I. Akbarali   +4 more
doaj   +1 more source

TDP1 deficiency sensitizes human cells to base damage via distinct topoisomerase I and PARP mechanisms with potential applications for cancer therapy [PDF]

, 2013
Base damage and topoisomerase I (Top1)-linked DNA breaks are abundant forms of endogenous DNA breakage, contributing to hereditary ataxia and underlying the cytotoxicity of a wide range of anti-cancer agents.
Alagoz, Boyd, Breslin, Caldecott, Chen, Chiang, Ciccia, Dalhus, Das, Demple, Dungey, El-Khamisy, Fu, Godon, Hecht, Hegde, Hudson, Interthal, Interthal, Kato, Katyal, Kummar, Lebedeva, Lindahl, Lindahl, Liu, Loeb, Luo, Madhusudan, Meisenberg, Meryem Alagoz, Mohammed, Morland, Murai, Murai, Nilsen, Owen S. Wells, Pommier, Pourquier, Povirk, Ray Chaudhuri, Rydberg, Sherif F. El-Khamisy, Strom, Sultana, Takashima, Wilson, Xanthoudakis, Yang, Zeng, Zhou   +50 more
core   +1 more source

Dysfunction of cortical GABAergic neurons leads to sensory hyper-reactivity in a Shank3 mouse model of ASD. [PDF]

, 2020
Hyper-reactivity to sensory input is a common and debilitating symptom in individuals with autism spectrum disorders (ASD), but the neural basis underlying sensory abnormality is not completely understood.
Chen, Naiyan, Chen, Qian, Deister, Christopher A, Dimidschstein, Jordane, Feng, Guoping, Feng, Shijing, Fishell, Gord, Gao, Xian, Goard, Michael J, Guo, Baolin, Liao, Weiping, Liu, Runpeng, Lu, Zhonghua, Lynn-Jones, Taylor, Moore, Christopher I, Shi, Yiwu, Wells, Michael F   +16 more
core   +1 more source

Transient receptor potential ankyrin 1 that is induced in dorsal root ganglion neurons contributes to acute cold hypersensitivity after oxaliplatin administration

Molecular Pain, 2015
BackgroundPeripheral cold neuropathic pain is a serious side effect of oxaliplatin treatment. However, the mechanism of oxaliplatin-induced cold hyperalgesia is unknown.
Ken Yamamoto, Noriko Chiba, T. Chiba, T. Kambe, K. Abe, K. Kawakami, I. Utsunomiya, K. Taguchi   +7 more
semanticscholar   +1 more source

Construction of a clickable probe‐based protein chip platform for discovering covalent mIDH1 inhibitors from natural medicinal extracts

iMeta, EarlyView.
In this study, we develop a flexible Ccc‐Chip (protein microarray + bioorthogonal click chemistry) for high‐throughput screening of natural covalent active molecules from medicinal plant extracts, identifying flavokawain C from Piper methysticum Forst as a novel covalent mIDH1 inhibitor.
Zhao Cui, Jiameng Li, Caifeng Li, Mo Sun, Wei Liu, Xuxia Cao, Shiwen Deng, Junxian Cao, Hongjun Yang, Peng Chen   +9 more
wiley   +1 more source