Results 181 to 190 of about 66,872 (284)

β‐Elemene Rescues Radiation‐Induced Enteritis by Orchestrating a Host‐Microbiome Circuit That Fuels Epigenetic DNA Repair

Advanced Science, EarlyView.
This study elucidates that β‐elemene promotes cellular uptake of L. gasseri‐derived lactate by enhancing the membrane translocation of MCT1 in a CD147‐dependent manner. Intracellular lactate, through the lactylation of RBBP4 at the K26 site, recruits EP300 to the promoter regions of downstream genes (POLD1/POLD3), catalyzing H3K27ac modification.
Jiancheng He, Jiapeng Bao, Shukang Deng, Weijie Zang, Haoming Yan, Zihao Zhao, Guangze Zhang, Ruiqing Liu, Junjie Chen, Yilin Hu, Wanjiang Xue   +10 more
wiley   +1 more source

Unbiased and error-detecting combinatorial pooling experiments with balanced constant-weight Gray codes for consecutive positives detection. [PDF]

Bioinformatics
He G, Kovaleva VA, Barton C, Thomas PG, Pogorelyy MV, Meyer HV, Huang Q.   +6 more
europepmc   +1 more source

Mechanisms of convective cloud organization by cold pools over tropical warm ocean during the AMIE/DYNAMO field campaign

This paper investigates the mechanisms of convective cloud organization by precipitation-driven cold pools over the warm tropical Indian Ocean during the 2011 Atmospheric Radiation Measurement (ARM) Madden-Julian Oscillation (MJO) Investigation ...
Feng, Zhe, Hagos, Samson, de Szoeke, Simon P., Burleyson, Casey D., Martini, Matus N., Rowe, Angela K.   +5 more
core  

An Integrated NLP‐ML Framework for Property Prediction and Design of Steels

Advanced Science, EarlyView.
This study presents a data‐driven framework that uses language‐processing techniques to interpret steel processing descriptions and machine‐learning models to predict mechanical properties. By organising complex process histories into meaningful groups and enabling rapid property forecasts, the work supports faster, more informed steel design through ...
Kiran Devraju, Adithya Umanath Rai, Jose Thomson, Marzie Ghorbani, Shujing Zhao, Nick Birbilis   +5 more
wiley   +1 more source

Response of Convection to Forcing That Creates a Cold Pool

SOLA
Satoh, Masaki, Nakai, Shunnosuke, Matsugishi, Shuhei   +2 more
openaire   +1 more source

Convective storms alter bioaerosol populations through cold pools and precipitation.

Environ Sci Atmos
Feldman TK, Mampage CBA, Falk NM, Fernando JC, Heffernan B, Hill TCJ, Juergensen D, Mignani C, Nieto-Caballero M, Grant LD, van den Heever SC, DeMott PJ, Kreidenweis SM, Perkins RJ, Stone EA.   +14 more
europepmc   +1 more source

Meet a Chemist Repurposing Tech from the 1850s to Fight Water Scarcity. [PDF]

ACS Cent Sci
Kruzman D.
europepmc   +1 more source

Pharmacologic Modulation of ARID3A with Rimegepant Reactivates Type I Interferon Signaling and Sensitizes Triple‐Negative Breast Cancer to PD‐1 Blockade

Advanced Science, EarlyView.
This study identifies ARID3A as a key immunosuppressive transcription factor in TNBC. Its inhibition activates the type I IFN pathway, boosting CD8+ T cell infiltration and sensitizing tumors to anti‐PD‐1. The FDA‐approved migraine drug Rimegepant targets ARID3A, enhances immunotherapy efficacy in preclinical models, and establishes a druggable axis to
Teng Zhou, Yifei Zhu, Cheng Zeng, Jinlu Han, Huiying Huang, Doudou Li, Mingxi Lin, Yizi Jin, Qin Guo, Yuxin Yan, Xinhui Mao, Yifei Zhou, Jian Zhang   +12 more
wiley   +1 more source

Harnessing Antioxidants for Abiotic Stress Management: Mechanistic Insights and Prospects for Sustainable Agriculture. [PDF]

Antioxidants (Basel)
Haider FU, Liu T, Aguila LCR, Shahzad B, Habiba, Zhang P, Li X.   +6 more
europepmc   +1 more source

Dose‐Dependent Reprogramming of Chromatin Accessibility by SOX4 Drives the Transcriptional Response to Iron Overload

Advanced Science, EarlyView.
This study demonstrates that iron overload triggers widespread chromatin compaction and transcriptional repression in human granulosa cells, recapitulating features of endometriosis. The epigenetic reprogramming is orchestrated by a TFEB‐SOX4‐SWI/SNF axis, with SOX4 acting as a central, dosage‐sensitive regulator.
Feifei Li, Yaoqiu Wu, Guangyu Yang, Jingyi Lai, Xiaoyue Sun, Liyan Wang, Xiaoli Li, Jing Zhang, Qingxue Zhang, Hui Chen, Haiyan Lin, Bingxiang Xu, Junfeng Zhang, Hailong Wang, Anming Meng, Chunwei Cao   +15 more
wiley   +1 more source