Results 201 to 210 of about 246,652 (294)

Intra-annual variability of the greenhouse gas balance of a sahelian rangeland ecosystem in semi-arid West Africa [PDF]

, 2018
Assouma, Mohamed Habibou, Bernouxe, M., Ganglof, J.C., Hiernaux, Pierre, Ickowicz, Alexandre, Lecomte, Philippe, Vayssières, Jonathan   +6 more
core  

Recent community warming of moths in Finland is driven by extinction in the north and colonisation in the south. [PDF]

Nat Commun
Ellis EE, Antão LH, Davrinche A, Mäkinen J, Rees M, Conenna I, Huikkonen IM, Leinonen R, Pöyry J, Suuronen A, Laine AL, Saastamoinen M, Vanhatalo J, Roslin T.   +13 more
europepmc   +1 more source

Combination Immunotherapy as a Promising Strategy to Overcome Immunotherapy Resistance: From Emergence to Next‐Generation Approaches

Advanced Science, EarlyView.
This review examines emerging combination immunotherapy strategies tailored to distinct tumor microenvironments and highlights next‐generation biomarkers that guide response prediction and treatment personalization. It integrates lessons from unsuccessful trials, addresses toxicity challenges, and outlines approaches for early biomarker discovery and ...
Asmita Pandey, Sudhir Kumar Rai, Li Ma, Lauren Higa, Vedbar Khadka, Hua Yang, Youping Deng   +6 more
wiley   +1 more source

Cold air pools in Seefeld

, 2022
openaire   +1 more source

Reduced Maintenance DNA Methylation Thresholds Enable Sensitive Reporter Assays for UHRF1 and DNMT1 Inhibition

Advanced Science, EarlyView.
The authors engineer colorectal cancer cells with reduced redundancy of UHRF1 and DNMT1, key DNA methylation maintenance factors, lowering the maintenance threshold and sensitizing cells to inhibition. They develop reporter assays driven by endogenous tumor‐suppressor gene promoters with enhanced sensitivity and dynamic range to demethylating drugs ...
Cuicui Xia, Ying Cui, Jiongliang Wang, Wenjing Bai, Danyang Wang, Yao Chen, Huahui Guo, Liangyi Zong, Bing Qin, Xintong Cai, Jie Wang, Jing Huang, Scott B. Rothbart, Zufeng Guo, Stephen B. Baylin, Xiangqian Kong   +15 more
wiley   +1 more source

Supercooled storage of red blood cells slows down the metabolic storage lesion. [PDF]

Sci Rep
Nemkov T, Isiksacan Z, William N, Senturk R, Boudreau LE, Yarmush ML, Acker JP, D'Alessandro A, Usta OB.   +8 more
europepmc   +1 more source

Activation of ERBB4 Pathway Inhibits Pathological Transdifferentiation of Lung Epithelial Progenitors into CD66c+ Basal Cells in Severe Lung Injury

Advanced Science, EarlyView.
In fibrotic distal lung regions, CD66c+ basal cells emerge as a pathological state. Using human distal lung organoids, this study identifies CD66c+ basal cells as a pro‐fibrotic state arising through transdifferentiation from secretory, AT2, and basal cells.
Kaijun Lin, Xinran Deng, Haonan Wang, Yamei Jiang, Jian Sun, Hailin Ding, Ming Ye, Xiaoting Wang, Yu Wang, Li Yuan, Zhenju Song, Xinhua Lin, Shenfei Sun, Ning Jiang   +13 more
wiley   +1 more source

A signaling hub in the mosquito rectum coordinates reproductive investment after blood feeding. [PDF]

Curr Biol
Greppi C, Frank K, Saltz V, Duvall LB.
europepmc   +1 more source

Proton FLASH Exposure Preserves Gut Commensal Microbiomes and Spares Intestinal Stem Cells

Advanced Science, EarlyView.
This study highlights the role of Proton FLASH abdominal irradiation in sparing of intestinal stem cells and preservation of key gut microbial population resulting minimization of radiation toxicity in intestinal epithelium in mice. Our findings support the potential of Proton FLASH to improve the therapeutic ratio for abdominal radiation exposure ...
Rishi Man Chugh, Payel Bhanja, Emily Schueddig, Jufri Setianegara, Yuting Lin, Kenny Guida, Shujah Rehman, Stacey Krepel, Devin Koestler, Ronald C. Chen, Katherine L. Cook, Subhrajit Saha   +11 more
wiley   +1 more source

Rubisco kinetic acclimation at the holoenzyme level. [PDF]

Proc Natl Acad Sci U S A
Askey B, Ceminsky M, Scott E, Wang Y, Oh ZG, Azinas S, Laganowsky A, Gunn LH.   +7 more
europepmc   +1 more source