Results 51 to 60 of about 1,101,024 (286)

Finite Element Simulation of Combined Forming of Selective Laser Sintering and Cold Isostatic Pressing

, 2010
Selective Laser Sintering could manufacture high complex metal parts in short time but with high porosity and low strength. The components from Cold Isostatic Pressing have excellent performance with uniform organizational structure, high size precision,
Yan Ying Du, Qing Song Wei, Yu Sheng Shi
core   +1 more source

The C‐terminal truncated splicing variant of NK1R negatively modulates substance P‐stimulated NK1R signaling

FEBS Open Bio, EarlyView.
The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen, Duc Trung Nguyen, Minyoung Cho, Jihun Kim, Soyeon In, Thai Uy Nguyen, Sunghoon Hurh, Beom Jin Park, Jong‐Ik Hwang   +8 more
wiley   +1 more source

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

FEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao, Xiaoting Kang, Lulu Meng, Shaoxuan Zhang, Qiujie Li, Jinyu Zhou, Mengyue Xue, Chu Li, Hua Zhu, Pengzhou Hang, Jing Zhao   +10 more
wiley   +1 more source

The Antioxidant Activity and Oxidative Stability of Cold‐Pressed Oils [PDF]

Journal of the American Oil Chemists' Society, 2014
AbstractIn our study, we characterized the antioxidant activity and oxidative stability of cold‐pressed macadamia, avocado, sesame, safflower, pumpkin, rose hip, Linola, flaxseed, walnut, hempseed, poppy, and milk thistle oils. The radical scavenging activity of the non‐fractionated fresh oil, as well as the lipophilic and hydrophilic fractions of the ...
Prescha, Anna, Grajzer, Magdalena, Dedyk, Martyna, Grajeta, Halina   +3 more
openaire   +3 more sources

Dactolisib outperforms Rapamycin in potentiating apoptosis induced by XPO1, Bcl‐2 and Mcl‐1 blockade in preclinical glioblastoma models

FEBS Open Bio, EarlyView.
The PAM pathway and its impact on cellular metabolism. Color‐coded key symbols represent Rapamycin (R, orange, targeting mTOR) and Dactolisib (D, green, targeting PI3K/mTOR), indicating their sites of action. Created with BioRenders.com. Glioblastoma resists therapy through interconnected survival programs.
Kai Zhao, Leonie Meyer, Madita Braun, Katharina Otte, Celine Bitter, Maite Pawlik, Hartmann Raifer, Frederik Helmprobst, Axel Pagenstecher, Hans Urban, Michael C. Burger, Michael W. Ronellenfitsch, Joachim P. Steinbach, Jarmila Jedelská, Shamim Bagheri, Behrooz H. Yousefi, Pietro Di Fazio, Markus Luster, Andreas H. Mahnken, Andreas Neubauer, Andreas Burchert, Christopher Nimsky, Jörg W. Bartsch, Tillmann Rusch   +23 more
wiley   +1 more source

Material Characterization and Remelting Behavior of Recycled Aluminum Briquettes Produced from Machining Chips

Applied Sciences
This study presents a material-level characterization of recycled aluminum briquettes produced by cold pressing Al–Si–Mg machining chips and investigates their behavior during subsequent remelting.
Jozef Mikita, Petr Baron, Ján Ivan
doaj   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Optimization of oil recovery from oilseed rape by cold pressing using statistical modeling

, 2023
Cold pressing is frequently used to produce high-quality vegetable oils, especially from seeds with high oil content, such as rapeseeds. But, it encounters a challenge from the industrial demand for high oil yield.
Grahovac, Nada, Mitrović, Petar, Marjanović-Jeromela, Ana, Troter, Dragan, Veljković, Vlada, Todorović, Zoran, Zlatković, Vesna, Banković-Ilić, Ivana   +7 more
core   +1 more source

Integrated PANoptosis Profiling Identifies Immunosuppressive Subtypes and a Prognostic Signature With Functional Validation of MLKL in Glioblastoma

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The prognosis of glioblastoma (GBM) remains highly unfavorable, largely due to high tumor heterogeneity and an immunosuppressive microenvironment. However, the functional role of PANoptosis in this context is poorly understood. Methods Patients were stratified via K‐means clustering. A risk score model was constructed using prognosis‐
Langfei Tian, Minghui Zhao, Yuanbo Hu, Kaiyue Wang, Haiguang Liu, Zetong Bai, Kebin Zheng   +6 more
wiley   +1 more source

Enhancing the performance and stability of carbon-based perovskite solar cells by the cold isostatic pressing method [PDF]

, 2017
The cold isostatic pressing method was used as a post-treatment process for enhancing the power conversion efficiency and stability of carbon-based perovskite solar cells without hole transport materials.
Ku, Zhiliang, Wangnan Li, Wang, Jize, Huang, Fuzhi, Li, Wangnan, Peng, Yong, Yangwen Zhang, Cheng, Yibing, Xue Liu, Zhang, Yangwen, Yibing Cheng, Zhong, Jie, Liu, Xue, Zhiliang Ku, Jize Wang, Yong Peng, Jie Zhong, Fuzhi Huang   +17 more
core   +1 more source