Results 91 to 100 of about 1,318,533 (304)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

An experimental study of polymer electrolyte fuel cell operation at sub-freezing temperatures [PDF]

open access: yes, 2013
The ability of polymer electrolyte fuel cells (PEFCs) to startup at subfreezing temperatures is governed by whether it is able to overcome the freezing point (0°C) before product ice prevents the electrochemical reactions. In this work, we experimentally
Borup, RL   +4 more
core   +2 more sources

Studies on the Cold Resistance of Cassava

open access: yesJournal of Agricultural Science, 2012
Methods: SC124 and Fuxuan 01, two cold-resistant cassava cultivars and Nanzhi199 and SC205, another two cold-sensitive cassava cultivars were studied under low temperature stress. Aims: in order to explore the hardy physiological characters of different cassava cultivars.
Xinglu Luo, Qiufeng Huang
openaire   +2 more sources

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

open access: yesFEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer   +7 more
wiley   +1 more source

Evaluation and ranking of candidate ceramic wafer engine seal materials [PDF]

open access: yes
Modern engineered ceramics offer high temperature capabilities not found in even the best superalloy metals. The high temperature properties of several selected ceramics including aluminum oxide, silicon carbide, and silicon nitride are reviewed as they ...
Steinetz, Bruce M.
core   +1 more source

Normal metal - superconductor tunnel junction as a Brownian refrigerator [PDF]

open access: yes, 2007
Thermal noise generated by a hot resistor (resistance $R$) can, under proper conditions, catalyze heat removal from a cold normal metal (N) in contact with a superconductor (S) via a tunnel barrier. Such a NIS junction acts as Maxwell's demon, rectifying
A. F. Andreev   +7 more
core   +2 more sources

On the resistance of aphides to severe cold [PDF]

open access: yesAnnals and Magazine of Natural History, 1880
(Uploaded by Plazi from the Biodiversity Heritage Library) No abstract provided.
openaire   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

open access: yesFEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner   +7 more
wiley   +1 more source

Оцінка інбредних ліній кукурудзи за ознакою холодостійкості та SSR маркерами

open access: yesPlant Varieties Studying and Protection, 2019
Мета. Класифікація вихідного матеріалу кукурудзи за ступенем холодостійкості, ідентифікація самозапилених ліній кукурудзи в лабораторних і польових умовах за холодостійкістю та основними господарсько-цінними показниками та їхнє генотипування на основі ...
В. Л. Жемойда   +5 more
doaj   +1 more source

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

open access: yesFEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose   +9 more
wiley   +1 more source

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