Results 101 to 110 of about 5,221,850 (348)

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Application of molecular genetic methods in rice breeding for cold resistance

Зерновое хозяйство России
Low positive temperatures have a negative impact on all processes occurring at all stages of rice development. This is especially true during the period of seed germination and sprouting, resulting in reduced seed energy and growth strength.
E. V. Dubina, Z. K. Kizi Olimova
doaj   +1 more source

N2 Gas Flushing Limits the Rise of Antibiotic-Resistant Bacteria in Bovine Raw Milk during Cold Storage [PDF]

, 2017
Antibiotic resistance has been noted to be a major and increasing human health issue. Cold storage of raw milk promotes the thriving of psychrotrophic/psychrotolerant bacteria, which are well known for their ability to produce enzymes that are frequently
Andremont, Anonymous, Aquilanti, Bari, Björck, Bonomo, Botelho, Chambers, Cousin, Dechemi, ECDC (European Centre for Disease Prevention Control) EFSA (European Food Safety Authority), EMA (European Medicines Agency), EUCAST, EUCAST, FAO, FAO, FAO, Forslund, Frank, Garofalo, Gaya, Gschwendtner, Hsu, Klappenbach, Kools, Lafarge, Lechner, Munsch-Alatossava, Munsch-Alatossava, Munsch-Alatossava, Munsch-Alatossava, Munsch-Alatossava, Munsch-Alatossava, Munsch-Alatossava, Munsch-Alatossava, Munsch-Alatossava, Murray, Pal, Pereira, Perreten, Raats, Rasolofo, Rolain, Seifu, SØrum, Tetra Pak, Teuber, Větrovsky, Wang, WHO, Wichmann, Wiedmann, Wolfson   +51 more
core   +2 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Exogenous Spermidine Alleviated Low-Temperature Damage by Affecting Polyamine Metabolism and Antioxidant Levels in Apples

Plants
Low-temperature stress significantly limits the growth, development, and geographical distribution of apple cultivation. Spermidine (Spd), a known plant growth regulator, plays a vital role in the plant’s response to abiotic stress.
Meiqi He, Jia Zhou, Deguo Lyu, Gongxun Xu, Sijun Qin   +4 more
doaj   +1 more source

Highly Abrasion-resistant and Long-lasting Concrete [PDF]

, 2019
Studded tire usage in Alaska contributes to rutting damage on pavements resulting in high maintenance costs and safety issues. In this study binary, ternary, and quaternary highly-abrasion resistant concrete mix designs, using supplementary cementitious ...
Liu, Jenny, Murph, Diane
core  

SmallTalk: a novel small‐sized fusion tag for peptide expression and purification

FEBS Open Bio, EarlyView.
The SmallTalk fusion tag allows for the efficient expression and purification of soluble recombinant proteins or peptides in Escherichia coli. Testing with SmallTalk‐GFP confirmed that the proteins were soluble and folded correctly, while SmallTalk‐Bin1b maintained its antimicrobial activity against various bacterial isolates. This streamlined workflow
Atika Tariq, Nestor G. Casillas‐Vega, Alma Gomez‐Loredo, Xristo Zarate   +3 more
wiley   +1 more source

Kappa Values in Testing the Concordance: Comments on a Recent Article about Nasopharyngeal Swabs for SARS-CoV-2 Detection

Microbiology Spectrum, 2022
Ming Li, Chi Zhang, Tianfei Yu
doaj   +1 more source

Mid-infrared LEDs versus thermal emitters in IR dynamic scene simulation devices [PDF]

, 2006
In a radical departure from conventional thermal emitter-based dynamic IR scene simulation devices, we have tested InAsSbP/InAs LEDs grown by liquid phase epitaxy and tuned at several peak-emitting wavelengths inside the mid-IR band.
Malyutenko, V. K., Zinovchuk, A. V.
core   +1 more source