Results 111 to 120 of about 34,834 (311)

ABHD17C‐Mediated S‐Depalmitoylation of BCL6B Enhances CD24 Transcription to Resist Macrophage Phagocytosis in Pancreatic Cancer

Advanced Science, EarlyView.
ABHD17C‐mediated depalmitoylation of BCL6B at Cys442 blocks its nuclear import and triggers ubiquitin‐dependent degradation, attenuating transcriptional repression of the anti‐phagocytic signal CD24. This mechanism enables pancreatic cancer cells to evade macrophage phagocytosis and fosters an immunosuppressive microenvironment.
Yalu Zhang, Di Cui, Fanzheng Meng, Xu Zhu, Liang Zhu, Liang Wu, Haifeng Hu, Jizhou Wang, Hanhui Yao, Lianxin Liu   +9 more
wiley   +1 more source

The improvement and verification of fluid dynamics simulation on temperature uniformity during heat treatment of ring pieces

Heliyon
The improvement and verification of fluid dynamics simulation on temperature uniformity during the heat treatment of ring pieces are investigated in this study.
Mingzhe Xu, Jinfu Zhao, Li Wang, Tengxiang Zhao, Ling Kong, Zhipeng Li, Zhixin Huang, Yuhui Wang   +7 more
doaj   +1 more source

Xenogeneic Mitochondrial Transplantation Improves Selected Age‐Associated Phenotypes in Mice

Advanced Science, EarlyView.
Yak‐derived xenogeneic mitochondrial transplantation improves selected age‐associated phenotypes in mice, enhances mitochondrial functional readouts, and engages host mitochondrial quality‐control pathways. Broad tissue biodistribution, increased ATP production and mtDNA copy number, reduced ROS levels and dysfunctional mitochondria, improved motility ...
Wenpeng Li, Xijia Wang, Yaning Hu, Zhen Yang, Tian Niu, Xingbo Zhao   +5 more
wiley   +1 more source

Mitochondrial Carrier SLC25A13 Drives Ferroptosis Resistance and Immune Evasion via a STAT3–IFI6 Circuit in Breast Cancer

Advanced Science, EarlyView.
SLC25A13 is identified as an immunometabolic driver of triple‐negative breast cancer that sustains ferroptosis resistance and immune evasion through a STAT3–IFI6 circuit. Pharmacologic degradation of SLC25A13 restores ferroptosis sensitivity and enhances anti‐PD‐1 efficacy, highlighting a strategy to convert immune‐cold tumors into immunotherapy ...
Yingze Zhu, Yuhan Tang, Yingcui Chen, Zhuoqi Zhang, Yige Lu, Xinyue Wang, Qiyuan Shi, Wenhui Zhao, Hui Pang   +8 more
wiley   +1 more source

Effect of rolling on fatigue crack growth rate of Wire and Arc Additive Manufacture (WAAM) processed Titanium [PDF]

, 2013
Titanium (Ti) alloys have been commonly used in the aerospace industry, not only because they have a high strength-to-weight ratio (comparing to the steels) but also their satisfactory corrosion resistance.
Qiu, Xundong
core  

Microstructure and mechanical properties of pure copper plate processed by novel dynamic offsets and shear force adjustment rolling

Journal of Materials Research and Technology
Asymmetric rolling is beneficial for grain refinement and properties improvement through mass production of metals. This study introduces a novel asymmetric rolling technology, known as dynamic offsets and shear force adjustment (DS) rolling.
Longfei Xu, Kai Yu, Li Wang, Shizhao Quan, Ling Kong, Haokun Yang, Xiaodan Zhang, Yan Peng, Yuhui Wang   +8 more
doaj   +1 more source

Synergistic Remodeling of Tumor Immune Microenvironment via a DNA Nanodevice Integrating STING Activation and Lysosome‐Targeted PD‐L1 Degradation

Advanced Science, EarlyView.
A rational design DNA nanoplatform not only achieves efficient PD‐L1 degradation but also triggers robust STING signaling. The nanodevice effectively reprograms “cold” tumors, leading to potent inhibition of tumor growth and metastasis in vivo. ABSTRACT The cGAS‐STING pathway is a cornerstone of innate antitumor immunity; however, its therapeutic ...
Haoxiang Li, Min Hou, Shasha Sun, Jun Cao, Jian‐Hui Jiang, Jianjun He   +5 more
wiley   +1 more source

Micro-plasto-hydrodynamic lubrication: a fundamental mechanism in cold rolling

, 2014
peer reviewedMicro Plasto-Hydrodynamic (MPH) lubrication is a general mechanism in metal forming that consists in a re-lubrication of tool-piece solid contacts by an outflow of lubricant from pressurized “pockets” promoted by the plastic deformation. MPH
Tornicelli, Maurice, Boman, Romain, Laugier, Maxime, Ponthot, Jean-Philippe, Bech, Jakob Ilsted, Legrand, Nicolas, Bech, Jacob, Ponthot, Jean Philippe, Carretta, Yves   +8 more
core   +1 more source

Analysis of Temperature and Stress Fields in the Process of Hot-Rolled Strip Coiling

Metals
During the coiling process of a hot-rolled strip, with the increasing layers the temperature and stress distribution inside the coil constantly change and interact with each other.
Meng Dai, Yuting Hu, Yanchao Hao, Ping Qiu, Hong Xiao   +4 more
doaj   +1 more source

Synergistic Stabilization of Potassium Metal Anodes Through Orange‐Peel Elimination and Robust Solid–Electrolyte Interphase Formation

Advanced Science, EarlyView.
Synergistic control of surface uniformity and solid–electrolyte interphase robustness regulates potassium deposition, suppressing dendritic growth and enabling uniform, dense potassium plating. This combined strategy promotes stable interfacial chemistry and homogeneous electric‐field distribution, leading to enhanced reversibility and long‐term ...
Pan He, Yupei Han, Yundong Zhou, Ruhan He, Rui Xu, Yunlong Zhao, Junjun Wang, Wanjun Ren, Matthew Hopper, Qinyou An, Denys Makarov, Ian S. Gilmore, Liqiang Mai, Yang Xu   +13 more
wiley   +1 more source