Results 171 to 180 of about 168,319 (335)

Pirin Transcriptionally Regulates PLA2G4A To Inhibit Ferroptosis in Colorectal Cancer via Lipid Profile Remodeling

Advanced Science, EarlyView.
This study identifies Pirin (PIR), an iron‐binding protein, as a critical ferroptosis suppressor in colorectal cancer through lipid membrane remodeling. PIR, induced by NRF2 during ferroptotic stress, transcriptionally regulates PLA2G4A to shift cellular lipid composition away from ferroptosis‐permissive polyunsaturated phospholipids.
Wei Shi, Yue Qi Ong, Prativa Majee, Esther SM Wong, Amhed Missael Vargas Velazquez, Kerem Fidan, Pierce Kah‐Hoe Chow, Wai Leong Tam, Ker Kan Tan, Iain Beehuat Tan, Vinay Tergaonkar   +10 more
wiley   +1 more source

The Marmara Sea Gateway since ~16 ky BP: non-catastrophic causes of paleoceanographic events in the Black Sea at 8.4 and 7.15 ky BP [PDF]

, 2007
The Late Quaternary history of connection of the Black Sea to the Eastern Mediterranean has been intensely debated. Ryan, Pitman and coworkers advocate two pulses of outflow from the Black Sea to the world ocean at ~16–14.7 ky BP and ~11–10 ky BP ...
Abrajano, T., Aksu, A.E., Hiscott, R.N., Kaminski, M.A., Mudie, P.J., Rochon, A., Yaşar, D.   +6 more
core  

Targeting the GPX4–FUNDC1 Interaction with Magnesium Lithospermate B Attenuates Sepsis‐Associated Lung Injury

Advanced Science, EarlyView.
The diagram depicts the endothelial‐protective mechanism of magnesium lithospermate B (MLB) in sepsis‐associated lung injury. MLB binds GPX4 at Gly79, disrupts its interaction with FUNDC1, prevents mitophagy‐mediated GPX4 degradation, restores mitophagic flux, reduces ROS, and limits ferroptosis.
Zhixi Li, Chang Liu, Zhaoxue Ma, Dongyou Zheng, Renkai Wang, Yongjing Yu, Guangmin Chen, Chenglong Li, Yue Bu, Hang Cao, Bing Zhang   +10 more
wiley   +1 more source

Effect of cold stratification treatments on germination of drought tolerant shrubs seeds.

Journal of environmental biology, 2008
This study was carried out to determine effects of different durations (20, 40, 60 days and control) of cold stratification treatments on seed germination and to overcome dormancy in seeds of twelve different drought tolerant plants. The species used in this study were Arbutus andrachne L., Cistus creticus L., Colutea armena Bois.
Zafer, Olmez, Fatih, Temel, Askin, Gokturk, Zeki, Yahyaoglu   +3 more
openaire   +1 more source

Targeting IL27RA Enhances Immunotherapy in Triple‐Negative Breast Cancer by Modulating Tumor Cells and the Tumor Microenvironment

Advanced Science, EarlyView.
IL27RA upregulation drives immune evasion in TNBC by suppressing MHC‐I expression and reprogramming T/NK‐cell states, establishing an immune‐excluded tumor phenotype. Targeting this epithelial‐intrinsic IL27RA–PI3K/AKT axis offers a promising strategy to overcome immunotherapy resistance.
Jiachi Xu, Qian Long, Meirong Zhou, Qitong Chen, Jing Peng, Qingchun Liang, Danhua Zhang, Hui Zhou, Wenjun Yi   +8 more
wiley   +1 more source

Changes in endogenous hormone contents of pear stock ( Pyrus betulaefolia Bge. and Pyrus calleryana Dcne.) seeds during cold stratification [PDF]

, 2011
Jianping Bao, Shaoling Zhang
openalex  

Seed-germination response of Leymus chinensis to cold stratification in a range of temperatures, light and low water potentials under salt and drought stresses

, 2017
Jixiang Lin, Yujie Shi, Tao Shuang, Xingyang Yu, Dafu Yu, Xiufeng Yan   +5 more
openalex   +2 more sources

Spatially Resolved Multiomics Reveals Metabolic Remodeling and Autophagy Activation in Adamantinomatous Craniopharyngiomas

Advanced Science, EarlyView.
Multiomics integration analysis reveals the “cystic fluid–tumor cell” metabolic coupling that mediates active choline/ethanolamine uptake of tumor cells from cystic fluid and PC/PE synthesis pathways reprogramming that mediating autophagy pathway activation within ACP. ABSTRACT Adamantinomatous craniopharyngioma (ACP), a benign yet highly recurrent and
Dongting Chen, Yahui Gao, Yulin Wang, Ting Lei, Zheng Qu, Yuhan An, Jiaxu Fu, Xin Li, Fangjun Liu, Yan Li   +9 more
wiley   +1 more source

The COLD-SAT Experiment for Cryogenic Fluid Management Technology [PDF]

Future national space transportation missions will depend on the use of cryogenic fluid management technology development needs for these missions. In-space testing will be conducted in order to show low gravity cryogenic fluid management concepts and to
Schuster, J. R., Vento, D. M., Wachter, J. P.   +2 more
core   +1 more source

Effects of cold stratification and sulphuric acid pretreatments on germination of three provenances of smoke-tree (Cotinus coggygria Scop.) seeds in greenhouse and laboratory conditions

, 2009
Zafer Ölmez, Aşkın Göktürk, Banu Karaşah, Hilal Yılmaz   +3 more
openalex   +2 more sources