Results 241 to 250 of about 1,310,937 (363)

Identification of histone deacetylase inhibitor targeting type I interferon and B‐cell abnormalities in systemic lupus erythematosus

Arthritis &Rheumatology, Accepted Article.
Objective Systemic lupus erythematosus (SLE) is characterized by increased type I interferon (IFN‐I) and autoantibody production. This study aimed to identify drugs that can inhibit both IFN‐I and autoantibody production. Methods We identified an inhibitor of IFN‐I production from a chemical library.
Takehiro Hirayama, Hachiro Konaka, Yasuhiro Kato, Takayuki Shibahara, Chisato Nishizawa, Kohei Tsujimoto, JeongHoon Park, Eri Itotagawa, Tatsunori Jo, Masayuki Nishide, Sumiyuki Nishida, Yoshihito Shima, Masashi Narazaki, Wataru Aoki, Ken J Ishii, Hyota Takamatsu, Atsushi Kumanogoh   +16 more
wiley   +1 more source

Drugs induced Raynaud's phenomenon and underlying mechanism: a disproportionality analysis from the WHO pharmacovigilance database

Arthritis &Rheumatology, Accepted Article.
Objectives The aim of this study is to generate hypotheses about unknown drugs associated with the onset or worsening of Raynaud's Phenomenon (RP) and to explore their potential pathophysiological mechanisms through a mixed disproportionality/clustering analysis from the WHO pharmacovigilance database.
Alex Hlavaty, Loubna Dari, Jean‐Luc Cracowski, Matthieu Roustit, Charles Khouri   +4 more
wiley   +1 more source

Autonomic dysfunction and insulin resistance in type 2 diabetes mellitus with hypoglycemia unawareness: an observational study. [PDF]

Cardiovasc Endocrinol Metab
Nandi D, Gupta S, Ajmera N, Selvaraj R, Gulati S, Zaheer S, Tomar A.   +6 more
europepmc   +1 more source

Altered Auditory Maturation in Fragile X Syndrome and Its Involvement in Audiogenic Seizure Susceptibility

Autism Research, EarlyView.
ABSTRACT Auditory hypersensitivity is a prominent symptom in Fragile X syndrome (FXS), the most prevalent monogenic cause of autism and intellectual disability. FXS arises through the loss of the protein encoded by the FMR1 (Fragile X Messenger Ribonucleoprotein 1) gene, FMRP, required for normal neural circuit excitability.
Dorit Möhrle, Demi Ma, Wenyue Xue, Jun Yan, Ning Cheng   +4 more
wiley   +1 more source

Seed size and cold stratification affect Acer negundo and Acer ginnala seeds germination

, 2020
О. А. Киселева, О Г Лоретц, Д. В. Веселкин   +2 more
openalex   +1 more source

Alternative Lengthening of Telomeres: A Prognostic Paradox in Cancer. [PDF]

Cells
Sung JY.
europepmc   +1 more source

Insights from meta‐analysis for efficient docosahexaenoic acid production in thraustochytrids through advanced cultivation and fermentation strategies

Biofuels, Bioproducts and Biorefining, EarlyView.
Abstract This systematic review examines strategies for docosahexaenoic acid (DHA) production by thraustochytrids, focusing on cultivation techniques, fermentation technologies, and carbon/nitrogen optimization to increase productivity. Among 169 eligible articles, the 100 most productive studies (0.7–10.3 g DHA L−1 per day) were analyzed. Quantitative
Jhiovana Cristielly Carrera Silva da Costa, Lucas Araújo Guimarães, Andre da Luz de Freitas, Luciana Porto de Souza Vandenberghe, Gilberto Vinícius de Melo Pereira, Carlos Ricardo Soccol, Hervé Louis Ghislain Rogez   +6 more
wiley   +1 more source

Clinical study on the effects of different cold compress methods and durations on postoperative complications following mandibular impacted third molar extraction. [PDF]

Front Surg
Xie Z, Zhang W, Du T, Wang Y, Wang J, Li J, Qu P.   +6 more
europepmc   +1 more source

Influence of Cold Stratification on Germination Success of Vegetative Propagules from Multiple Butomus Umbellatus Aflp Genotypes

Bradley Sartain, Nathan E. Harms, Andrew B. Coomes   +2 more
openalex   +1 more source

Adaptive Algal Cultivation Enabled by a Monthly Biomass Forecasting System

Biotechnology and Bioengineering, EarlyView.
The developed monthly algal forecasting system used to predict biomass production for two algal strains (A and B) at two pond water depths (low and high). The highest predicted production, achieved with strain A at a low pond water depth, is selected as the cultivation strategy to guide the next month's algal growth.
Hongxiang Yan, Song Gao, Mark S. Wigmosta, Andre M. Coleman, Ning Sun, Michael H. Huesemann   +5 more
wiley   +1 more source