Results 111 to 120 of about 8,965,053 (394)

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Kinetics of indirect excitons in the optically-induced exciton trap

, 2007
We report on the kinetics of a low-temperature gas of indirect excitons in the optically-induced exciton trap. The excitons in the region of laser excitation are found to rapidly -- within 4 ns -- cool to the lattice temperature T = 1.4 K, while the ...
A. C. Gossard, A. L. Ivanov, A. T. Hammack, L. Mouchliadis, L. V. Butov, L. V. Keldysh, L. V. Keldysh, P. C. M. Christianen   +7 more
core   +1 more source

Characterizing epithelial‐mesenchymal transition‐linked heterogeneity in breast cancer circulating tumor cells at a single‐cell level

Molecular Oncology, EarlyView.
In over 50% of non‐metastatic breast cancer patients, circulating tumor cells (CTCs) along the whole epithelial‐mesenchymal transition spectrum are detected. Total CTC number and individual phenotypes relate to aggressive disease characteristics, including lymph node involvement and higher tumor proliferation. At the single‐cell level, mesenchymal CTCs
Justyna Topa, Julia Richert, Tomasz Stokowy, Alicja Staśczak, Mariusz Szajewski, Maciej Ciesielski, Petra M. Grešner, Bartłomiej Tomasik, Łukasz Arcimowicz, Agnieszka Stankiewicz, Grażyna Suchodolska, Elżbieta Senkus, Wiesław Kruszewski, Anna J. Żaczek, Aleksandra Markiewicz   +14 more
wiley   +1 more source

Effect Of Cold On Growth Of Fungal Elements In Clinical Specimens

پیاورد سلامت, 2016
Background and Aim: In medical centers, after obtaining visceral clinical samples in suitable containers under certain circumstances, they are sent to mycology laboratory.
Ghafur Tavakoli, Roshanak Daei, Farshad Hashemi, Mehdi Zarei, Hoda Deli, Seyed Jamal Hashemi   +5 more
doaj  

Comment on: "Sadi Carnot on Carnot's theorem"

, 2003
Carnot established in 1824 that the efficiency $\eta_{C}$ of reversible engines operating between a hot bath at absolute temperature $T_{hot}$ and a cold bath at temperature $T_{cold}$ is equal to $1-T_{cold}/T_{hot}$.
Arnaud, Jacques, Chusseau, Laurent, Philippe, Fabrice   +2 more
core   +1 more source

Critical Review of Theoretical Models for Anomalous Effects (Cold Fusion) in Deuterated Metals

, 2003
We briefly summarize the reported anomalous effects in deuterated metals at ambient temperature, commonly known as "Cold Fusion" (CF), with an emphasis on important experiments as well as the theoretical basis for the opposition to interpreting them as ...
A. A. Shihab-Elden, A. B. Karabut, A. Burrows, A. Einstein, A. G. W. Cameron, A. J. Leggett, A. J. Leggett, A. O. Barut, A. Takahashi, A. Takahashi, A. V. Arzhannikov, B. A. Mamyrin, B. F. Bush, B. Y. Liaw, B. Y. Liaw, C. D. Siclen Van, C. Petrillo, D. Bohm, E. R. Harrison, E. Storms, E. Storms, E. Tabet, E. Tabet, E. Tabet, E. W. Becker, F. C. Frank, F. Celani, F. E. Cecil, F. G. Will, F. G. Will, F. J. Mayer, F. Liu, F. Paneth, F. Paneth, G. F. Cerofolini, G. Gamow, G. L. Shaw, G. Lin, G. P. Chambers, G. Preparata, G. Preparata, G. Preparata, G. S. Chulick, G. S. Chulick, H. Takahashi, J. A. McNeil, J. D. Jackson, J. F. Benesh, J. F. Ziegler, J. O. Bockris, J. R. Oppeenheimer, J. R. Spence, J. R. Spence, J. Rafelski, J. Russell, J. Russell, J. Russell, J. S. Cohen, J. Schwinger, J. Schwinger, J. Yang, K. B. Whaley, K. Cedzynska, K. Cedzynska, K. F. Wolf, K. Szalewicz, L. Alvarez, L. G. Sobotka, L. L. Lohr, L. Pauling, L. S. Celenza, L. Turner, M. Cribier, M. Danos, M. Danos, M. Fleischmann, M. Gryzinsky, M. Jandel, M. Jandel, M. Rabinowitz, M. Rabinowitz, M. Rabinowitz, M. Rambaut, M. Srinivasan, M. Srinivasan, M. Y. Azbel, N. J. C. Packham, O. H. Crawford, P. B. Price, P. I. Goluburchiy, P. L. Hagelstein, P. L. Hagelstein, P. L. Hagelstein, R. A. Rice, R. A. Rice, R. Fukuda, R. H. Dicke, R. H. Parmenter, R. H. Parmenter, R. L. Garwin, R. L. Mills, R. L. Mills, R. T. Bush, R. Taniguchi, S. E. Jones, S. E. Koonin, S. R. Chubb, S. R. Chubb, T. Bressani, T. Claytor, T. Dickenson, V. A. Chechin, V. A. Khiev, V. A. Tsarev, V. A. Tsarev, V. A. Tsarev, V. C. Noninski, V. F. Zelensky, V. F. Zelensky, V. I. Vysotskii, V. Pokropivny, W. A. Fowler, W. Kolos, Y. E. Kim, Y. E. Kim, Y. E. Kim, Y. E. Kim, Y. E. Kim, Y. E. Kim, Y. E. Kim, Y. E. Kim, Y. E. Kim, Y. E. Kim, Y. N. Bazhutov, Z. Sun   +134 more
core   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source

Cold temperatures put a freeze on myosin activation [PDF]

Journal of General Physiology, 2019
JGP study reveals that low temperatures reduce force production in mammalian skeletal muscle by trapping myosin motors in a refractory state unable to bind actin.
openaire   +3 more sources

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source