Results 91 to 100 of about 5,544,180 (301)

Salmonella enterica serovar typhi limits the potency of typhoid toxin and ADP‐ribosylating toxin AB to establish a persistent infection

FEBS Open Bio, EarlyView.
The two catalytic subunits of typhoid toxin dissociate from the holotoxin in the ER of an intoxicated cell, but only CdtB exits the ER to generate immunosuppressive effects. PltA is retained in the ER and sequestered from its cytosolic target, thus allowing the anti‐inflammatory effects of CdtB to promote intestinal colonization.
Maria C. Zabala‐Rodriguez, Juliette K. Tinker, Teresa Frisan, Taj Azarian, Ken Teter   +4 more
wiley   +1 more source

150 Years of temperature-related excess mortality in the Netherlands [PDF]

Even in present-day high-income countries, there is a lot of evidence of a high degree of vulnerability of the population to both high and low outdoor temperatures.
Coen van Duin, Peter Ekamper, Joop Garssen, Frans van Poppel   +3 more
core  

Cell surface CD11c as a neutrophil aging marker molecule

FEBS Open Bio, EarlyView.
Cell surface CD11chi neutrophils were more aged and had better phagocytic function than CD11c−/lo neutrophils. Transcriptomic analysis of CD11chi neutrophils and CD11c−/lo neutrophils in pediatric population showed that the most difference was seen in infants.
Sophia Koutsogiannaki, Fahd Alhamdan, Erik Malm, Marie Bermudez, Samuel Y. Kim, Koichi Yuki   +5 more
wiley   +1 more source

Effects of high temperature and CO₂ on intracellular DMSP in the cold-water coral Lophelia pertusa [PDF]

, 2014
Significant warming and acidification of the oceans is projected to occur by the end of the century. CO₂ vents, areas of upwelling and downwelling, and potential leaks from carbon capture and storage facilities may also cause ...
Carruthers, Madeleine, Burdett, Heidi, Roberts, J.M., Hennige, Sebastian J, Burdett, H.L., Donohue, Penelope, Roberts, J Murray, Carruthers, M, Wicks, L C, H L Burdett (7885532), Roberts, J. M., Roberts, Murray, Donohue, P J C, Hennige, S. J., Kamenos, N.A., Wicks, L. C., S J Hennige (8009348), Wicks, Laura, Kamenos, Nicholas, Hennige, S.J., P J C Donohue (8009345), Donohue, P.J.C., Donohue, P. J. C., Carruthers, M., M Carruthers (8009342), Wicks, L.C., L C Wicks (8005697), Kamenos, N A, Kamenos, Nicholas A.,, Burdett, H. L., Kamenos, N. A., Burdett, H L, N A Kamenos (7885541), Hennige, Sebastian, J Murray Roberts (7884155)   +34 more
core   +1 more source

The C‐terminal truncated splicing variant of NK1R negatively modulates substance P‐stimulated NK1R signaling

FEBS Open Bio, EarlyView.
The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen, Duc Trung Nguyen, Minyoung Cho, Jihun Kim, Soyeon In, Thai Uy Nguyen, Sunghoon Hurh, Beom Jin Park, Jong‐Ik Hwang   +8 more
wiley   +1 more source

Private heat for public warmth: how huddling shapes individual thermogenic responses of rabbit pups [PDF]

, 2012
<p><b>Background:</b> Within their litter, young altricial mammals compete for energy (constraining growth and survival) but cooperate for warmth.
Caroline Gilbert, André Ancel, Blanc, S., Dominic J McCafferty, Ancel, André, Stéphane Blanc, Mccafferty, Dominic J, Giroud, Sylvain, Ancel, A., Gilbert, Caroline, Giroud, S., Blanc, Stéphane, Gilbert, C., Sylvain Giroud, McCafferty, D.J., Giroud Sylvain, Blanc Stéphane, Gilbert Caroline, McCafferty Dominic J., Ancel André   +19 more
core   +2 more sources

Cold Temperature and Cardiovascular Mortality

Circulation Journal, 2013
Athyros, Vasilios G, Katsiki, Niki, Karagiannis, Asterios   +2 more
openaire   +6 more sources

Changes in Physicochemical Properties of Wild and Cultivated Blackberry during Postharvest Cold Storage

Journal of Food Quality and Hazards Control, 2021
Background: Blackberry is a seasonal harvested fruit that is also very fragile and perishes quickly. A comparative study was conducted to find out influence of cold storage on physicochemical parameters of wild and cultivated blackberry over a period of ...
N. Azzouzi, S. Zantar, N. Aghmir, M.R. Britel, A. Maurady   +4 more
doaj  

The Ethylene Signaling Pathway Negatively Impacts CBF/DREB-Regulated Cold Response in Soybean (Glycine max)

Frontiers in Plant Science, 2019
During cold stress, soybean CBF/DREB1 transcript levels increase rapidly; however, expected downstream targets appear unresponsive. Here, we asked whether the ethylene signaling pathway, which is enhanced in the cold can negatively regulate the soybean ...
Jennifer D. Robison, Yuji Yamasaki, Stephen K. Randall   +2 more
doaj   +1 more source

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

FEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao, Xiaoting Kang, Lulu Meng, Shaoxuan Zhang, Qiujie Li, Jinyu Zhou, Mengyue Xue, Chu Li, Hua Zhu, Pengzhou Hang, Jing Zhao   +10 more
wiley   +1 more source