Results 1 to 10 of about 1,395,133 (120)
Rates of contributory de novo mutation in high and low-risk autism families
Communications Biology, 2021 Yoon, Munoz, et al. investigate the rate of de novo coding and non-coding variants in families with high- and low-risk for autism using whole-genome sequence data from collections of families with autism.
Seungtai Yoon +16 more
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Management, Analyses, and Distribution of the MaizeCODE Data on the Cloud
Frontiers in Plant Science, 2020 MaizeCODE is a project aimed at identifying and analyzing functional elements in the maize genome. In its initial phase, MaizeCODE assayed up to five tissues from four maize strains (B73, NC350, W22, TIL11) by RNA-Seq, Chip-Seq, RAMPAGE, and small RNA ...
Liya Wang +22 more
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MaTAR25 lncRNA regulates the Tensin1 gene to impact breast cancer progression
Nature Communications, 2020 A group of long non-coding RNAs (lncRNAs), Mammary Tumor Associated RNA s 1-30 (MaTARs 1-30), are differentially expressed between mammary tumor cells and normal mammary epithelial cells. Here the authors report that MaTAR25 plays a role in breast cancer
Kung-Chi Chang +13 more
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Dicer promotes genome stability via the bromodomain transcriptional co-activator BRD4
Nature Communications, 2022 While RNA interference is conserved across species, small RNA pathways are very diverse. In this study, Gutbrod et al. find that non-canonical roles of Dicer in genome stability are in fact deeply conserved from yeast to humans.
M. J. Gutbrod +6 more
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Cell Reports, 2023 Summary: Social sensitivity to other individuals in distress is crucial for survival. The anterior cingulate cortex (ACC) is a structure involved in making behavioral choices and is influenced by observed pain or distress. Nevertheless, our understanding
Alberto Corona +4 more
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Gene-specific nonsense-mediated mRNA decay targeting for cystic fibrosis therapy
Nature Communications, 2022 The W1282X nonsense mutation in the CFTR gene causes cystic fibrosis by reducing its mRNA and functional protein levels. Here the authors developed antisense-oligonucleotide cocktails that restore CFTR protein function by gene-specific stabilization of ...
Young Jin Kim +5 more
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Prevalent and dynamic binding of the cell cycle checkpoint kinase Rad53 to gene promoters
eLife, 2022 Replication of the genome must be coordinated with gene transcription and cellular metabolism, especially following replication stress in the presence of limiting deoxyribonucleotides.
Yi-Jun Sheu +3 more
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eLife, 2021 The origin recognition complex (ORC) cooperates with CDC6, MCM2-7, and CDT1 to form pre-RC complexes at origins of DNA replication. Here, using tiling-sgRNA CRISPR screens, we report that each subunit of ORC and CDC6 is essential in human cells. Using an
Hsiang-Chen Chou +12 more
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BET Bromodomain Inhibition Releases the Mediator Complex from Select cis-Regulatory Elements
Cell Reports, 2016 The bromodomain and extraterminal (BET) protein BRD4 can physically interact with the Mediator complex, but the relevance of this association to the therapeutic effects of BET inhibitors in cancer is unclear.
Anand S. Bhagwat +5 more
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Rapid and tunable method to temporally control gene editing based on conditional Cas9 stabilization
Nature Communications, 2017 CRISPR/Cas9-based genome editing enables specific deletion of target genes. Here, Senturket al. develop an inducible editing system by fusing a conditional destabilization domain to Cas9 and demonstrate temporal control of gene editing in response to a ...
Serif Senturk +9 more
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