Results 41 to 50 of about 2,218,582 (300)

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Specificity, synergy, and mechanisms of splice-modifying drugs

Nature Communications
Drugs that target pre-mRNA splicing hold great therapeutic potential, but the quantitative understanding of how these drugs work is limited. Here we introduce mechanistically interpretable quantitative models for the sequence-specific and concentration ...
Yuma Ishigami, Mandy S. Wong, Carlos Martí-Gómez, Andalus Ayaz, Mahdi Kooshkbaghi, Sonya M. Hanson, David M. McCandlish, Adrian R. Krainer, Justin B. Kinney   +8 more
doaj   +1 more source

Fn14 is an activity-dependent, Bmal1-regulated cytokine receptor that induces rod-like microglia and restricts neuronal activity in vivo

Cell Reports
Summary: Cytokines and their receptors play important roles in brain development and aging-related disease, but their functions within the healthy adult brain remain poorly understood.
Austin Ferro, Dominic J. Vita, Trevor Fallon, Anosha Arshad, Leah Boyd, Tess Stanley, Qianyu Lin, Adrian Berisha, Uma Vrudhula, Adrian M. Gomez, Irene Sanchez-Martin, Jeremy C. Borniger, Lucas Cheadle   +12 more
doaj   +1 more source

MELK expression correlates with tumor mitotic activity but is not required for cancer growth

eLife, 2018
The Maternal Embryonic Leucine Zipper Kinase (MELK) has been identified as a promising therapeutic target in multiple cancer types. MELK over-expression is associated with aggressive disease, and MELK has been implicated in numerous cancer-related ...
Christopher J Giuliano, Ann Lin, Joan C Smith, Ann C Palladino, Jason M Sheltzer   +4 more
doaj   +1 more source

Revisiting the cold case of cold fusion

Nature, 2019
The 1989 claim of 'cold fusion' was publicly heralded as the future of clean energy generation. However, subsequent failures to reproduce the effect heightened scepticism of this claim in the academic community, and effectively led to the disqualification of the subject from further study.
Berlinguette, Curtis P, Chiang, Yet-Ming, Munday, Jeremy N, Schenkel, Thomas, Fork, David K, Koningstein, Ross, Trevithick, Matthew D   +6 more
openaire   +4 more sources

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Effects of chronic cold treatment on root elongation and gene expression in "Arabidopsis thaliana" [PDF]

, 2008
Low temperature is a major limitation of plant growth. Cold adaptation is important for the survival and distribution of plant species at high elevations and high latitudes.
Lee, Yang Ping
core   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Water supply in cold regions

, 2020
WATER SUPPLY IN COLD REGIONS Amos J. Al ter January 1969 GB 2401 ,U58m lll-C5a 1969 LD U.S. ARMY MA T ERIE L COMMAND TERRE S TRIA L SCIENCES CENTER REGIONS RESEARCH A ENGINEERING LABORATORY HANOVER, NEW HAMPSHIRE T H I S D O C U M E N T H A S B E E N A P
Cold Regions Research and Engineering Laboratory (U.S.)
core  

Presence of Insulin-Like Growth Factor Binding Proteins Correlates With Tumor-Promoting Effects of Matrix Metalloproteinase 9 in Breast Cancer

Neoplasia: An International Journal for Oncology Research, 2015
The stroma of breast cancer can promote the disease’s progression, but whether its composition and functions are shared among different subtypes is poorly explored.
Jae-Hyun Park, Morten Grønbech Rasch, Jing Qiu, Ida Katrine Lund, Mikala Egeblad   +4 more
doaj   +1 more source