Results 21 to 30 of about 2,218,582 (300)
British Medical Bulletin, 1948 In the spring of 1946, a group of us working under the Medical Research Council felt that the time was ripe for a renewed onslaught on the difficult problem of the common cold. We have since learnt that, at about the same time, several groups of workers in the United States had much the same idea.
openaire +7 more sources
P53 Mutations Change Phosphatidylinositol Acyl Chain Composition
Cell Reports, 2015 Phosphatidylinositol phosphate (PIP) second messengers relay extracellular growth cues through the phosphorylation status of the inositol sugar, a signal transduction system that is deregulated in cancer.
Adam Naguib +9 more
doaj +1 more source
Neural Networks With Motivation
Frontiers in Systems Neuroscience, 2021 Animals rely on internal motivational states to make decisions. The role of motivational salience in decision making is in early stages of mathematical understanding.
Sergey A. Shuvaev +5 more
doaj +1 more source
The Cold Peace: Russo-Western Relations as a Mimetic Cold War [PDF]
, 2013 In 1989–1991 the geo-ideological contestation between two blocs was swept away, together with the ideology of civil war and its concomitant Cold War played out on the larger stage.
Sakwa, Richard, Richard Sakwa
core +1 more source
Bio-Protocol, 2021 Flow cytometry is a popular laser-based technology that allows the phenotypic and functional characterization of individual cells in a high-throughput manner.
Ana Almeida, Miriam Fein, Mikala Egeblad
doaj +1 more source
Regulation of Chandelier Cell Cartridge and Bouton Development via DOCK7-Mediated ErbB4 Activation
Cell Reports, 2014 Chandelier cells (ChCs), typified by their unique axonal morphology, are the most distinct interneurons present in cortical circuits. Via their distinctive axonal terminals, called cartridges, these cells selectively target the axon initial segment of ...
Yilin Tai +3 more
doaj +1 more source
Sensitive, non-immunogenic in vivo imaging of cancer metastases and immunotherapy response
Cell Stress, 2023 Non-invasive imaging of tumors expressing reporter transgenes is a popular preclinical method for studying tumor development and response to therapy in vivo due to its ability to distinguish signal from tumors over background noise. However, the utilized
Joseph R. Merrill +8 more
doaj +1 more source
TP63-Mediated Enhancer Reprogramming Drives the Squamous Subtype of Pancreatic Ductal Adenocarcinoma
Cell Reports, 2018 Summary: The aberrant expression of squamous lineage markers in pancreatic ductal adenocarcinoma (PDA) has been correlated with poor clinical outcomes. However, the functional role of this putative transdifferentiation event in PDA pathogenesis remains ...
Tim D.D. Somerville +8 more
doaj +1 more source
PTPN23-dependent ESCRT machinery functions as a cell death checkpoint
Nature CommunicationsCell death plasticity is crucial for modulating tissue homeostasis and immune responses, but our understanding of the molecular components that regulate cell death pathways to determine cell fate remains limited.
Dongyan Song +10 more
doaj +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source