Results 31 to 40 of about 2,218,582 (300)
Trafficking and localization of KNOTTED1 related mRNAs in shoot meristems
Communicative & Integrative Biology, 2022 Multicellular organisms use transcripts and proteins as signaling molecules for cell-to-cell communication. Maize KNOTTED1 (KN1) was the first homeodomain transcription factor identified in plants, and functions in maintaining shoot stem cells.
Munenori Kitagawa +2 more
doaj +1 more source
Cold stress and the cold pressor test
Advances in Physiology Education, 2013 Temperature and other environmental stressors are known to affect blood pressure and heart rate. In this activity, students perform the cold pressor test, demonstrating increased blood pressure during a 1- to 2-min immersion of one hand in ice water. The cold pressor test is used clinically to evaluate autonomic and left ventricular function.
Dee U, Silverthorn, Joel, Michael
openaire +2 more sources
An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
FEBS Letters, EarlyView.Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Low Fatigue Response of Crest-Fixed Cold-Formed Steel Drape Curved Roof Claddings [PDF]
, 2018 Cold-formed steel roof claddings are subjected to significant suction/uplift pressures during high wind events. In New Zealand, the strong prevailing winds makes this a common occurrence. Suction pressures are generated by the turbulence of the wind flow
Lim, J. B. +9 more
core
Area postrema neurons mediate interleukin-6 function in cancer cachexia
Nature CommunicationsInterleukin-6 (IL-6) has been long considered a key player in cancer cachexia. It is believed that sustained elevation of IL-6 production during cancer progression causes brain dysfunctions, which ultimately result in cachexia. However, how peripheral IL-
Qingtao Sun +9 more
doaj +1 more source
Biological Psychiatry Global Open Science, 2021 Background: Substantial evidence indicates that a microdeletion on human chromosome 16p11.2 is linked to neurodevelopmental disorders, including autism spectrum disorder (ASD).
Jacqueline Giovanniello +3 more
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Structure of human CALHM1 reveals key locations for channel regulation and blockade by ruthenium red
Nature Communications, 2023 Calcium homeostasis modulator 1 (CALHM1) is a voltage-dependent channel involved in neuromodulation and gustatory signaling. Despite recent progress in the structural biology of CALHM1, insights into functional regulation, pore architecture, and channel ...
Johanna L. Syrjänen +3 more
doaj +1 more source
Bio-Protocol, 2022 The importance of studying the mechanistic aspects of long non-coding RNAs is being increasingly emphasized as more and more regulatory RNAs are being discovered.
Allen Yu +3 more
doaj +1 more source