Results 91 to 100 of about 43,879 (263)

The first contacts between Lithuanian and Swedish orthopedic surgeons after the Cold War. [PDF]

Acta Orthop, 2022
Hansson N, Padrini G, Halling T, Söhner F.   +3 more
europepmc   +1 more source

“No, no, the cold war was not that dramatic”

History Education Research Journal, 2019
History, for some students, is a complicated subject. For example, topics regarding politics and nation formation, on which history textbooks typically focus (Foster & Crawford, 2006), are difficult for students to imagine (Lévesque, 2008). Students need to create a context to understand such historical events and developments.
de Leur, Tessa, van Boxtel, Carla, Huijgen, Tim   +2 more
openaire   +2 more sources

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Disaggregated Perspectives on Civil War and Ethnic Conflict : Prospects of an Emerging Research Agenda [PDF]

Journal on Ethnopolitics and Minority Issues in Europe, 2009
After the end of the Cold War, international relations scholars studying violent conflict took note of the fact that since 1945, the most common and lethal form of organized violence was intra- rather than interstate war.
Tim Dertwinkel
doaj  

Oncolytic Adenoviruses: The Cold War against Cancer Finally Turns Hot. [PDF]

Cancers (Basel), 2022
Oronsky B, Gastman B, Conley AP, Reid C, Caroen S, Reid T.   +5 more
europepmc   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

The origin story of rapamycin: systemic bias in biomedical research and cold war politics. [PDF]

Mol Biol Cell, 2022
Powers T.
europepmc   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Radiation Risk in Cold War Mexico: Local and Global Networks. [PDF]

NTM, 2022
Barahona A.
europepmc   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source