Results 101 to 110 of about 3,064,809 (249)

Dactolisib outperforms Rapamycin in potentiating apoptosis induced by XPO1, Bcl‐2 and Mcl‐1 blockade in preclinical glioblastoma models

FEBS Open Bio, EarlyView.
The PAM pathway and its impact on cellular metabolism. Color‐coded key symbols represent Rapamycin (R, orange, targeting mTOR) and Dactolisib (D, green, targeting PI3K/mTOR), indicating their sites of action. Created with BioRenders.com. Glioblastoma resists therapy through interconnected survival programs.
Kai Zhao, Leonie Meyer, Madita Braun, Katharina Otte, Celine Bitter, Maite Pawlik, Hartmann Raifer, Frederik Helmprobst, Axel Pagenstecher, Hans Urban, Michael C. Burger, Michael W. Ronellenfitsch, Joachim P. Steinbach, Jarmila Jedelská, Shamim Bagheri, Behrooz H. Yousefi, Pietro Di Fazio, Markus Luster, Andreas H. Mahnken, Andreas Neubauer, Andreas Burchert, Christopher Nimsky, Jörg W. Bartsch, Tillmann Rusch   +23 more
wiley   +1 more source

Neoconservatives and Eternal Cold War

Scienza & Politica, 2019
The article discusses the genesis of U.S. neoconservatism – understood primarily as intellectual movement and political pressure group – and its foreign policy positions from the 1970s to today.
Mario Del Pero
doaj   +1 more source

Exploring Culture in and of the Cold War

, 2018
The Cold War used to be portrayed as a global struggle between the United States and the Soviet Union. Even if this image has been challenged many times, the main images that come to mind when speaking of the Cold War, are often linked to superpower ...
Parkkinen, Jari, Jari Parkkinen, Scott-Smith, Giles, Giles Scott-Smith, Simo Mikkonen, Mikkonen, Simo   +5 more
core   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

The making of the global economy: International law and the Global South

Leiden Journal of International Law
Across a fractured geopolitical landscape, the Global South faces renewed constraints on its capacity to pursue sovereign development. Rather than treating these pressures as symptoms of a ‘new Cold War’, this article returns to the original Cold War as ...
Luis Eslava
doaj   +1 more source

[Rethinking the Cold War? New Studies on the Cold War]. [PDF]

Neue Polit Lit, 2022
Bönker K.
europepmc   +1 more source

Memory and Resting‐State Connectivity in Acute Transient Global Amnesia: A Case–Control fMRI Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Objectives Transient global amnesia (TGA) is a striking model of isolated amnesia. While hippocampal lesions are well described, the network‐level mechanisms and the precise neuropsychological profile remain debated. Our objective was thus to characterize functional and neuropsychological correlates of acute TGA and their ...
Elias El Otmani, Emmanuel Barbeau, Béatrice Lemesle, Emilie Milongo‐Rigal, Sophie Fernandez, Sandrine Charpentier, Jean‐François Albucher, Nicolas Raposo, Fabrice Bonneville, Patrice Péran, Jérémie Pariente   +10 more
wiley   +1 more source

The Vaccination Cold War. [PDF]

Hastings Cent Rep, 2021
Moreno JD, Sándor J, Schmidt U.
europepmc   +1 more source

Integrated PANoptosis Profiling Identifies Immunosuppressive Subtypes and a Prognostic Signature With Functional Validation of MLKL in Glioblastoma

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The prognosis of glioblastoma (GBM) remains highly unfavorable, largely due to high tumor heterogeneity and an immunosuppressive microenvironment. However, the functional role of PANoptosis in this context is poorly understood. Methods Patients were stratified via K‐means clustering. A risk score model was constructed using prognosis‐
Langfei Tian, Minghui Zhao, Yuanbo Hu, Kaiyue Wang, Haiguang Liu, Zetong Bai, Kebin Zheng   +6 more
wiley   +1 more source

A Second Cold War? Explaining Changes in the American Discourse on China: Evidence from the Presidential Debates (1960-2020). [PDF]

J Chin Polit Sci, 2023
Marandici I.
europepmc   +1 more source