Results 211 to 220 of about 293,895 (310)

Evolving Real‐World Data and Evidence Use for New Drugs and Regenerative Medical Products Approvals in Japan—An Analysis of the 6‐Year Trend

Clinical Pharmacology &Therapeutics, EarlyView.
Several regulatory initiatives have been made to clarify the acceptability and requirements of real‐world data and real‐world evidence (RWD/E) for the benefit/risk assessment of new medical products in Japan. The objectives of this review were to characterize the use of RWD/E in regulatory applications of new medical products and to describe the ...
Suguru Okami, Kako Shimotsumagari, Yasunari Sadatsuki   +2 more
wiley   +1 more source

Incidence and Prognostic Factors for Colectomy in Acute Severe Ulcerative Colitis with Concomitant CMV Infection. [PDF]

Diseases
Kitsou K, Chalakatevaki K, Kokkotis G, Papathanasiou E, Kitsou V, Michopoulos S, Zampeli E, Bamias G.   +7 more
europepmc   +1 more source

Intestinal Barrier Glycosylation for Gut Physiology and Pathology

Barrier Immunity, EarlyView.
ABSTRACT The intestinal barrier is a selective structure that safeguards the body from external threats while permitting nutrient absorption and immune surveillance. It consists of the outer mucus layer, the intermediate layer of intestinal epithelial cells (IECs), and the inner layer of immune cells. The proteins in the mucus layer and within IECs are
Girak Kim, Deji Ye, Yikun Yao, Chuan Wu
wiley   +1 more source

Rectal treatment in ulcerative colitis; a qualitative study exploring reasons for under utilisation. [PDF]

Front Health Serv
Rothen JP, Moerlen F, von Büren C, Allemann S, Arnet I.   +4 more
europepmc   +1 more source

Gut‐microbiota‐brain Axis and post‐traumatic epilepsy

Epilepsia Open, EarlyView.
Abstract There has been growing evidence that perturbations in gut‐microbiota‐brain axis (GMBA) are involved in mechanisms of chronic sequelae of traumatic brain injury (TBI). This review discusses the connection between GMBA and post‐traumatic epilepsy (PTE), the latter being a common outcome of TBI.
Andrey Mazarati
wiley   +1 more source

Autoimmune Thyroid Diseases and Microscopic Colitis: A Nationwide Matched Case-Control Study in Sweden.

J Clin Endocrinol Metab
Bergman D, Kang X, Sun J, Ebrahimi F, Ludvigsson JF.   +4 more
europepmc   +1 more source

Efficacy of 2,4-Dinitrobenzenesulfonic Acid (DNBS) in the Maintenance of a Model of Inflammatory Bowel Disease in Pigs (<i>Sus scrofa domestica</i>). [PDF]

Int J Mol Sci
Szkopek D, Woliński J, Kopiasz Ł, Dziendzikowska K, Zaworski K, Sapierzyński R, Gromadzka-Ostrowska J.   +6 more
europepmc   +1 more source

Intestinal microbiome alterations in pediatric epilepsy: Implications for seizures and therapeutic approaches

Epilepsia Open, EarlyView.
Abstract The intestinal microbiome plays a pivotal role in maintaining host health through its involvement in gastrointestinal, immune, and central nervous system (CNS) functions. Recent evidence underscores the bidirectional communication between the microbiota, the gut, and the brain and the impact of this axis on neurological diseases, including ...
Teresa Ravizza, Greta Volpedo, Antonella Riva, Pasquale Striano, Annamaria Vezzani   +4 more
wiley   +1 more source

A Rare Case of Pyoderma Gangrenosum as a Complication of Ulcerative Colitis: A Case Report and Literature Review. [PDF]

Clin Case Rep
Shah A, Sharma A, Dahal A, Shrestha P, Parajuli R, Pradhan R, Shrestha B.   +6 more
europepmc   +1 more source

THE SURGERY OF COLITIS [PDF]

BMJ, 1909
openaire   +3 more sources