Results 31 to 40 of about 940,030 (267)

Safety and Effectiveness of a High‐Dose, Tailored Tissue Plasminogen Activator Therapy Protocol: A Joint Pediatric Hematology and Cardiac ICU Quality Improvement Initiative Analysis

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Pediatric thromboembolism is increasingly encountered in critical care. Systemic thrombolysis with tissue plasminogen activator (tPA) facilitates vessel or valve patency, yet pediatric‐specific protocols remain undefined, and safety concerns persist. Objective To evaluate the efficacy and safety of a tailored, prolonged systemic tPA
Eran Shostak, Oded Gilad, Yael Feinstein, Sigal Nakav, Ofer Schiller, Joanne Yacobovich   +5 more
wiley   +1 more source

Adjusting vector surveillance for human behaviors reveals Anopheles funestus drove a resurgence in malaria despite IRS with clothianidin in Uganda

Scientific Reports
After remarkable success following the implementation of indoor residual spraying (IRS) and repeated rounds of universal distribution of insecticidal treated nets in Tororo District, eastern Uganda, a switch to clothianidin-based IRS in March 2020 was ...
Paul Krezanoski, Alex Musiime, Ambrose Oruni, Max McClure, Patrick Kyagamba, Geoffrey Otto, James Adiga, Odol Wilfred, Moses Semakula, Jackson Asiimwe Rwatooro, Kilama Maxwell, Neil F. Lobo, Emmanuel Arinaitwe, Joaniter I. Nankabirwa, Moses Kamya, Grant Dorsey, Edward K. Thomsen   +16 more
doaj   +1 more source

Cardio-centric hemodynamic management improves spinal cord oxygenation and mitigates hemorrhage in acute spinal cord injury

Nature Communications, 2020
Clinical neuroprotective strategies for acute spinal cord injury (SCI) have largely overlooked the heart. Here the authors show cardiac contractility is immediately impaired in a porcine model of T2 SCI, and cardio-centric treatment with dobutamine ...
Alexandra M. Williams, Neda Manouchehri, Erin Erskine, Keerit Tauh, Kitty So, Katelyn Shortt, Megan Webster, Shera Fisk, Avril Billingsley, Alex Munro, Seth Tigchelaar, Femke Streijger, Kyoung-Tae Kim, Brian K. Kwon, Christopher R. West   +14 more
doaj   +1 more source

Prevalence of undetectable and suppressed viral load in HIV-infected pregnant women initiating Option B+ in Uganda: an observational study nested within a randomized controlled trial

BMC Infectious Diseases, 2021
Background Viral load (VL) testing is key in monitoring adherence to antiretroviral therapy (ART) and documenting HIV treatment response. As per HIV treatment guidelines in Uganda, the first VL test is recommended 6 months after initiation of ART ...
Grace Gabagaya, Gordon Rukundo, Alexander Amone, Priscilla Wavamunno, Joyce Namale-Matovu, Irene Lubega, Clemensia Nakabiito, Zikulah Namukwaya, Monica Nolan, Samuel S. Malamba, Rachel King, Jaco Homsy, Mary Glenn Fowler, Philippa Musoke   +13 more
doaj   +1 more source

A Situational Assessment of the Diagnostic Landscape and Organizational Readiness to Implement Next‐Generation Sequencing at Two Childhood Cancer Treatment Centers in Ghana

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Purpose Next‐generation sequencing (NGS) has emerged as a promising approach to improve diagnostic accuracy, but its feasibility in low‐ and middle‐income countries remains unknown. This study characterized the diagnostic landscape and assessed organizational readiness for NGS implementation at two childhood cancer treatment centers in Accra ...
Melissa Carvalho, Emmanuella Amoako, Nihad Salifu, Lily Gloria Tagoe, Yaw Bediako, Michelle Hermiston, Catherine Segbefia   +6 more
wiley   +1 more source

Therapeutic Apheresis in Nigeria: A Multi‐Center Summary of Abstracts From the Inaugural Nigerian Society for Apheresis Scientific Meeting

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Therapeutic apheresis (TA) is an established treatment modality for hematologic, neurologic, and immunologic disorders, yet access remains severely limited in sub‐Saharan Africa. Donor apheresis, including platelet apheresis collection from healthy donors, represents an important complementary modality supporting blood product ...
Nosa Bazuaye, Chimezie Okwuonu, Evelyn Idam, Folasade Adelekan‐Popoola, Shakirat Gold‐Olufadi, Olufunto Olufela Kalejaiye, Abdullateef Ogala, Zinnah Aloziem, Blossom Amamchukwu, Patience Elimia, Mkpoikanabasi Obot‐Obot, Henry Mbakwe, Praises Maduagwuna, Olatunji Akinrodoye, Chiamaka Anyanwu, Benjamin Anyanwu, Adedamola Akinsiku, Oluwatoyin A. Akinsiku, Muzamil O. Hassan, Fatiu A. Arogundade, Olalekan E. Ojo, Homayemem Weli, Jesupelumi Adenihun, Aderemi Adelaja, Ebun Bamgboye, Olalekan Olatise, Ade E. Faponle, Ayoola Odeyemi, Michael Muoka, Stephen Asaolu, Qudrat Busari, Blessing Dawudu, Michael Naiyeju, Rasheed A. Balogun   +33 more
wiley   +1 more source

Decreased susceptibility of Plasmodium falciparum to both dihydroartemisinin and lumefantrine in northern Uganda

Nature Communications, 2022
In this work, susceptibilities to two key antimalarials, dihydroartemisinin and lumefantrine, were associated with multiple genetic polymorphisms in Plasmodium falciparum, and were lower in northern Uganda, where resistance-mediating mutations have ...
Patrick K. Tumwebaze, Melissa D. Conrad, Martin Okitwi, Stephen Orena, Oswald Byaruhanga, Thomas Katairo, Jennifer Legac, Shreeya Garg, David Giesbrecht, Sawyer R. Smith, Frida G. Ceja, Samuel L. Nsobya, Jeffrey A. Bailey, Roland A. Cooper, Philip J. Rosenthal   +14 more
doaj   +1 more source

Collaboration, collaboration, collaboration!

, 2007
What should your three main priorities be as a Scientist? Collaboration, collaboration, collaboration.
openaire   +1 more source

Establishing an Apheresis Medicine Program in a Resource‐Constrained Setting: A 5‐Year Experience From Lagos, Nigeria

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Establishing a comprehensive apheresis medicine program in a resource‐constrained setting presents significant structural, financial, and logistical challenges. Despite the growing clinical importance of apheresis services globally, published experience from sub‐Saharan Africa remains sparse.
Folasade Adelekan‐Popoola, Shakirat Gold‐Olufadi, Olufunto Olufela Kalejaiye, Abdullateef Ogala, Rasheed A. Balogun   +4 more
wiley   +1 more source

Maternal care interventions for pregnant women with diabetes: A systematic review of antenatal education, diet, physical activity, and weight management

Pregnancy
Introduction Pregnant women with diabetes and their babies are at increased risk of adverse maternal and neonatal outcomes. Non‐pharmacological interventions, such as diabetes education, dietary and physical activity advice, and weight management, may ...
Gemma Villanueva, Brian Buckley, Katrin Probyn, Jennifer Petkovic, Heather McIntosh, Ferruccio Pelone, Fatema Kazi, Meghan Sebastianski, Hanna Bergman, Yanina Sguassero, Elise Cogo, Nicholas Henschke   +11 more
doaj   +1 more source