Results 51 to 60 of about 940,030 (267)

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Marked reduction in antibiotic usage following intensive malaria control in a cohort of Ugandan children

BMC Medicine, 2021
Background Intensive malaria control may have additional benefits beyond reducing the incidence of symptomatic malaria. We compared antibiotic treatment of children before and after the implementation of highly effective malaria control interventions in ...
Paul J. Krezanoski, Michelle E. Roh, John Rek, Joaniter I. Nankabirwa, Emmanuel Arinaitwe, Sarah G. Staedke, Susan Nayiga, Michelle S. Hsiang, David Smith, Moses Kamya, Grant Dorsey   +10 more
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

LLIN evaluation in Uganda project (LLINEUP2): association between housing construction and malaria burden in 32 districts

Malaria Journal
Background Well-built housing limits mosquito entry and can reduce malaria transmission. The association between community-level housing and malaria burden in Uganda was assessed using data from randomly selected households near 64 health facilities in ...
Samuel Gonahasa, Martha Nassali, Catherine Maiteki‑Sebuguzi, Jane F. Namuganga, Jimmy Opigo, Isaiah Nabende, Jaffer Okiring, Adrienne Epstein, Katherine Snyman, Joaniter I. Nankabirwa, Moses R. Kamya, Grant Dorsey, Sarah G. Staedke   +12 more
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Patient partnership in primary health care systems of the future: a structured priority setting exercise

Research Involvement and Engagement
Background Primary health care (PHC) provides holistic care to patients across the lifespan and offers a whole-society approach to health and wellbeing. PHC services are accessed by more people than any other type of healthcare in Ontario.
Rebecca Ganann, Maggie MacNeil, Aya Tagami, Jennifer Boyle, Clare Cruickshank, Aref Alshaikhahmed, Joan Barker, JoAnn Stans, Ashley Chisholm, Gulafroz Akbari, Ron Beleno, Mary Huang, Caron Leid, Vivian R. Ramsden   +13 more
doaj   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

To collaborate or not to collaborate: understanding human-robot collaboration

2022 IEEE 18th International Conference on Automation Science and Engineering (CASE), 2022
Villani, Valeria, Ciaramidaro, Angela, Iani, Cristina, Rubichi, Sandro, Sabattini, Lorenzo   +4 more
openaire   +3 more sources