Results 61 to 70 of about 940,030 (267)

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Collaboration [PDF]

Proceedings of the ACM international conference companion on Object oriented programming systems languages and applications companion, 2010
Steven Fraser 0001, Hannah Faye Chua, Gail E. Harris, Orit Hazzan, Jean Tabaka, Rob Tucker, Dave West   +6 more
openaire   +3 more sources

Recent Advancements, Challenges, and Future Directions of Integrating Drones in Smart City Traffic Management: A Systematic Review

Journal of Electrical and Computer Engineering
The implementation of unmanned aerial vehicles (UAVs) or drones has gained immense attention in recent years due to their high potential in enhancing traffic management in a smart city context.
Jiehan Teoh, Zi Xuan Lim, Yong Hang Chan, Ahnaf Shabab Kabir, Kian Meng Yap   +4 more
doaj   +1 more source

Collaborative Procrastination.

, 2020
The problem of inconsistent planning in decision making, which leads to undesirable effects such as procrastination, has been studied in the behavioral-economics literature, and more recently in the context of computational behavioral models. Individuals, however, do not function in isolation, and successful projects most often rely on team work.
Aris Anagnostopoulos, Aristides Gionis, Nikos Parotsidis   +2 more
openaire   +5 more sources

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

“After a long day of play, I get tired and forget to unfurl my bed net”: a qualitative study exploring factors affecting insecticide-treated bed net use among school-aged children in eastern Uganda

Malaria Journal
Background Despite widespread access to long-lasting insecticidal nets, infection with malaria parasites remains prevalent among African school-aged children.
Deborah Ekusai Sebatta, Sarah Alexander, John Rek, Maato Zedi, Emmanuel Arinaitwe, Mallory O. Johnson, Joaniter I. Nankabirwa, Moses R. Kamya, Grant Dorsey, Paul J. Krezanoski   +9 more
doaj   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

The Uganda housing modification study - association between housing characteristics and malaria burden in a moderate to high transmission setting in Uganda

Malaria Journal
Background Scale up of proven malaria control interventions has not been sufficient to control malaria in Uganda, emphasizing the need to explore innovative new approaches. Improved housing is one such promising strategy.
Joaniter I. Nankabirwa, Samuel Gonahasa, Agaba Katureebe, Peter Mutungi, Martha Nassali, Moses R. Kamya, Nelli Westercamp   +6 more
doaj   +1 more source

An overview of osteopathy graduates’ perceived preparedness at transition from educational environment to clinic environment one year after graduation: a cross sectional study

BMC Medical Education, 2018
Background This study investigated perceived preparedness to practice, one year after graduation across osteopathic education institutions (OEIs) and explored possible differences between countries where osteopathy is regulated (Reg) and countries where ...
E. Luciani, G. Consorti, P. L. S. van Dun, O. Merdy, C. Lunghi, M. Petracca, J. E. Esteves, F. Cerritelli   +7 more
doaj   +1 more source