Results 61 to 70 of about 634,428 (265)

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

open access: yesFEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens   +8 more
wiley   +1 more source

Developing Collaborative XML Editing Systems [PDF]

open access: yes, 2007
In many areas the eXtensible Mark-up Language (XML) is becoming the standard exchange and data format. More and more applications not only support XML as an exchange format but also use it as their data model or default file format for graphic, text and ...
Gerlicher, Ansgar Robert Sandy
core  

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

open access: yesMolecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain   +10 more
wiley   +1 more source

A Framework for collaborative writing with recording and post-meeting retrieval capabilities

open access: yes, 2004
From a HCI perspective, elucidating and supporting the context in which collaboration takes place is key to implementing successful collaborative systems.
King, David   +3 more
core  

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

open access: yesMolecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena   +15 more
wiley   +1 more source

Collaborative Environments. Considerations Concerning Some Collaborative Systems [PDF]

open access: yes
It is obvious, that all collaborative environments (workgroups, communities of practice, collaborative enterprises) are based on knowledge and between collaboration and knowledge management there is a strong interdependence.
Mihaela I. MUNTEAN
core  

Properties of the Collaborative Systems Metrics [PDF]

open access: yes
The paper describes the key properties of the collaborative systems. There are presented main quality characteristics for the collaborative systems. The paper analyzes different types of indicators. They represent the base for further metrics definition.
ION IVAN, Cristian CIUREA, Adrian VISOIU
core   +2 more sources

Handwritten text recognition using deep learning techniques: A survey [PDF]

open access: yesMATEC Web of Conferences
HTR (Handwritten Text Recognition) is the automated process of converting handwritten text into digital text, holding immense value in digitizing historical records and facilitating data entry.
Rakesh S.   +3 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

open access: yesMolecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura   +19 more
wiley   +1 more source

Interaction in collaborative writing between international and domestic students in an Indonesian university

open access: yesStudies in English Language and Education, 2020
This research investigates verbal interaction in collaborative writing between students from two countries with different L1 when writing an academic essay in a foreign language writing class.
Dwi Rahayu
doaj   +1 more source

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