Results 51 to 60 of about 421,736 (299)

Revisiting the 'Missing Middle' in English Sub-National Governance [PDF]

, 2010
In the light of the new Coalition Government’s proposed ‘rescaling’ of sub-national governance away from the regional level, it is an opportune time to re-consider the strength and weaknesses of the city or sub-regional approach to economic development ...
Ayres S., Burch M., Centre for Cities, the Work Foundation and SURF, Cheshire P., Conservative Party, Conservative Party, Departments of Business, Innovation and Skills, Communities and Local Government and HM Treasury, Goodchild B., Harding A., Harding A., Harrison J., Harrison J., HM Treasury, BERR &, HM Treasury, ODPM &, House of Commons, IPPR, Keith Shaw, Local Government Association, Mawson J., Neuman M., New Local Government Network, New Local Government Network, Northern Way, Office of the Deputy Prime Minister, Office of the Deputy Prime Minister, Organisation for Economic Co-operation and Development, Parr J., Paul Greenhalgh, Pearce G., Pike A., Robinson F., Rodriguez-Pose A., Rodriguez-Pose A., Scott A., Senior D., Stoker G., Tees Valley Joint Strategy Unit, Tees Valley Joint Strategy Unit, Tees Valley Unlimited, The Work Foundation   +39 more
core   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

How Should the Effectiveness of Marine Functional Zoning in China Be Evaluated? Taking Wenzhou Marine Functional Zoning as an Example

Land, 2022
Marine functional zoning is a basic form of marine management proposed and organized by the Chinese government in the late 1980s, and the third round of planning and implementation has been completed.
Renfeng Ma, Jiarui Chen, Qi Pan, Yuxian Cheng, Weiqin Wang, Baoyu Zhu, Jingwu Ma, Jiaming Li   +7 more
doaj   +1 more source

Rescaling the state in Flanders: new problem or old solution? [PDF]

, 2012
The rescaling of state emphasizes the rise of the regional and the city-regional scale in particular, as a new unit for policy making. The new governing strategy is referred to as regional governance, were both governmental and / or nongovernmental ...
De Rynck, Filip, Temmerman, Caroline, Voets, Joris, Wayenberg, Ellen   +3 more
core  

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

State-centred-collaborative-governance: A “new” governance model for ICT success

Cogent Social Sciences, 2022
This article proposes a new concept—state-centered-collaborative-governance—that describes and explains the ICT governance model and its success in Sweden.
Ke Yu
doaj   +1 more source

Turning Contention into Collaboration: Engaging Power, Trust, and Learning in Collaborative Networks [PDF]

, 2016
Given the complexity and multiplicity of goals in natural resource governance, it is not surprising that policy debates are often characterized by contention and competition.
Bell, Kathleen P., Calhoun, Aram J. K., Johnson, Teresa R., Levesque, Vanessa R.   +3 more
core   +3 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Knowledge integration in One Health policy formulation, implementation and evaluation [PDF]

, 2018
The One Health concept covers the interrelationship between human, animal and environmental health and requires multistakeholder collaboration across many cultural, disciplinary, institutional and sectoral boundaries.
Aenishaenslin, Assmuth, Baltussen, Barbara Häsler, Bergmann, Bots, Boyle, Cash, Chaffin, Cork, de Savigny, Dietz, Dodgson, Dörner, El Allaki, Frankson, Galaz, Hitziger, Jahn, Jann, Khoury, Klein, Körner, Lane, Lane, Lang, Lebov, Lee, Lee, Martin Hitziger, Massimo Canali, Maurizio Aragrande, Mbabu, Montibeller, Munaretto, Okello, Paternoster, Pohl, Queenan, Rasmussen, Roberto Esposito, Rosenhead, Rüegg, Scholz, Scholz, Shiroyama, Simon R Rüegg, Sripa, von Winterfeldt, Wickson, Woods, Zinsstag   +51 more
core   +3 more sources