Results 11 to 20 of about 437,388 (294)
Collagen density promotes mammary tumor initiation and progression [PDF]
BMC Medicine, 2008 Background Mammographically dense breast tissue is one of the greatest risk factors for developing breast carcinoma. Despite the strong clinical correlation, breast density has not been causally linked to tumorigenesis, largely because no animal model ...
Knittel Justin G +7 more
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Hypoxic Tumor Microenvironments Reduce Collagen I Fiber Density
Neoplasia: An International Journal for Oncology Research, 2010 Although the mechanisms through which hypoxia influences several phenotypic characteristics such as angiogenesis, selection for resistance to apoptosis, resistance to radiation and chemotherapy, and increased invasion and metastasis are well ...
Samata M. Kakkad +7 more
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Phase-field collagen fibrils: Coupling chirality and density modulations [PDF]
Physical Review Research, 2020 To describe the interaction between longitudinal density modulations along collagen fibrils (the D band) with a radial twist field of molecular orientation (double twist), we couple a phase-field crystal (PFC) with liquid-crystalline free energies to ...
Samuel Cameron +2 more
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Collagen Matrix Density Drives the Metabolic Shift in Breast Cancer Cells [PDF]
EBioMedicine, 2016 Increased breast density attributed to collagen I deposition is associated with a 4–6 fold increased risk of developing breast cancer. Here, we assessed cellular metabolic reprogramming of mammary carcinoma cells in response to increased collagen matrix ...
Brett A. Morris +8 more
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Highly motile cells are metabolically responsive to collagen density. [PDF]
Proc Natl Acad Sci U S A, 2022 Altered tissue mechanics and metabolism have gained significant attention as drivers of tumorigenesis, and mechanoresponsive metabolism has been implicated in migration and metastasis. However, heterogeneity in cell populations makes it difficult to link changes in behavior with metabolism, as individual cell behaviors are not necessarily reflected in ...
Zanotelli MR +5 more
europepmc +3 more sources
Cell jamming in a collagen-based interface assay is tuned by collagen density and proteolysis. [PDF]
J Cell Sci, 2023 ABSTRACT Tumor cell invasion into heterogenous interstitial tissues consisting of network-, channel- or rift-like architectures involves both matrix metalloproteinase (MMP)-mediated tissue remodeling and cell shape adaptation to tissue geometry.
Beunk L +10 more
europepmc +3 more sources
Collagen Density Modulates the Immunosuppressive Functions of Macrophages [PDF]
The Journal of Immunology, 2020 Abstract Tumor-associated macrophages (TAMs) support tumor growth by suppressing the activity of tumor-infiltrating T cells. Consistently, TAMs are considered a major limitation for the efficacy of cancer immunotherapy. However, the molecular reason behind the acquisition of an immunosuppressive TAM phenotype is not fully clarified ...
Anne Mette H Larsen +9 more
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Modeling stretch-dependent collagen fiber density
Mechanics Research Communications, 2021 Abstract Collagen is a load bearing constituent in many soft tissues, which undergoes remodeling processes that are mediated by mechanical stimuli. Experiments suggest that fiber stretching tends to suppress the enzymatic degradation of the collagen fibers.
Heiko Topol +2 more
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3D Cancer Models: The Need for a Complex Stroma, Compartmentalization and Stiffness
Frontiers in Bioengineering and Biotechnology, 2021 The use of tissue-engineered 3D models of cancer has grown in popularity with recent advances in the field of cancer research. 3D models are inherently more biomimetic compared to 2D cell monolayers cultured on tissue-culture plastic.
Judith Pape, Mark Emberton, Umber Cheema
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Majalah Obat Tradisional, 2022 The essential oil of lavender, lemon, and cinnamon (LaLC) combination is rich in antioxidants and potentially be used as an anti-wrinkle and strengthens the collagen tissue.
Hardi Astuti Witasari +5 more
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