Results 1 to 10 of about 2,942,836 (290)

Collagen density regulates the activity of tumor-infiltrating T cells [PDF]

Journal for ImmunoTherapy of Cancer, 2019
Background Tumor progression is accompanied by dramatic remodeling of the surrounding extracellular matrix leading to the formation of a tumor-specific ECM, which is often more collagen-rich and of increased stiffness.
Dorota E. Kuczek, Anne Mette H. Larsen, Marie-Louise Thorseth, Marco Carretta, Adrija Kalvisa, Majken S. Siersbæk, Ana Micaela C. Simões, Anne Roslind, Lars H. Engelholm, Elfriede Noessner, Marco Donia, Inge Marie Svane, Per thor Straten, Lars Grøntved, Daniel H. Madsen   +14 more
doaj   +8 more sources

Cell jamming in a collagen-based interface assay is tuned by collagen density and proteolysis. [PDF]

J Cell Sci, 2023
ABSTRACT Tumor cell invasion into heterogenous interstitial tissues consisting of network-, channel- or rift-like architectures involves both matrix metalloproteinase (MMP)-mediated tissue remodeling and cell shape adaptation to tissue geometry.
Beunk L, Wen N, van Helvert S, Bekker B, Ran L, Kang R, Paulat T, Syga S, Deutsch A, Friedl P, Wolf K.   +10 more
europepmc   +3 more sources

The effect of red fruit oil (Pandanus conoideus Lamk.) emulgel on angiogenesis and collagen density in incisive wound healing in mice (Mus musculus) [PDF]

Journal of Advanced Pharmaceutical Technology & Research, 2023
Pandanus conoideus Lamk. or commonly known as red fruit oil (RFO) can be used to accelerate wound healing because it contains tocopherols, carotenoids, oleic acid, linoleic acid, and linolenic acid.
Ria Ramadhani Dwi Atmaja, Veny Khairani Annadiyah, Maulida Thoyyibah, Siti Maimunah, Burhan Ma'arif, Roihatul Mutiah, I Made Budi, Muhammad Amiruddin, Fidia Rizkiah Inayatilah   +8 more
doaj   +2 more sources

Highly motile cells are metabolically responsive to collagen density. [PDF]

Proc Natl Acad Sci U S A, 2022
Altered tissue mechanics and metabolism have gained significant attention as drivers of tumorigenesis, and mechanoresponsive metabolism has been implicated in migration and metastasis. However, heterogeneity in cell populations makes it difficult to link changes in behavior with metabolism, as individual cell behaviors are not necessarily reflected in ...
Zanotelli MR, Zhang J, Ortiz I, Wang W, Chada NC, Reinhart-King CA.   +5 more
europepmc   +3 more sources

Polychlorinated Biphenyls (PCBs) Impact Prostatic Collagen Density and Bladder Volume in Young Adult Mice Exposed during in Utero and Lactational Development [PDF]

Toxics, 2023
Polychlorinated biphenyls (PCBs) are persistent organic pollutants linked to deleterious health outcomes, including voiding dysfunction in developmentally exposed mice.
Audrey Spiegelhoff, Kathy Wang, Monica Ridlon, Thomas Lavery, Conner L. Kennedy, Serena George, Kimberly P. Keil Stietz   +6 more
doaj   +2 more sources

Spatial Configurations of 3D Extracellular Matrix Collagen Density and Anisotropy Simultaneously Guide Angiogenesis. [PDF]

PLoS Computational Biology, 2023
Extracellular matrix (ECM) collagen density and fibril anisotropy are thought to affect the development of new vasculatures during pathologic and homeostatic angiogenesis.
Steven A LaBelle, A Marsh Poulson, Steve A Maas, Adam Rauff, Gerard A Ateshian, Jeffrey A Weiss   +5 more
doaj   +2 more sources

Dual-Energy Computed Tomography Collagen Density Mapping of the Cranio-Cervical Ligaments—A Retrospective Feasibility Study [PDF]

Diagnostics, 2022
The objectives of this study were to investigate the mean collagen content of the atlanto-axial joint (AAJ) ligaments in a cohort without inflammatory disease and to analyze clinical confounders such as age, sex, and presence of ligamentous ...
Thomas Matthias Wittig, Katharina Ziegeler, Virginie Kreutzinger, Milen Golchev, Simon Ponsel, Torsten Diekhoff, Sevtap Tugce Ulas   +6 more
doaj   +2 more sources

Reprogramming bone progenitor identity and potency through control of collagen density and oxygen tension [PDF]

iScience, 2022
Summary: The biophysical microenvironment of the cell is being increasingly used to control cell signaling and to direct cell function. Herein, engineered 3D tuneable biomimetic scaffolds are used to control the cell microenvironment of Adipose-derived ...
Rawiya Al Hosni, Laurent Bozec, Scott J. Roberts, Umber Cheema   +3 more
doaj   +2 more sources

Mechanism of the effect of Piper crocatum extract on wound healing of Wistar rats post-excision mammary tumor based on IL-10 level, TGF-β1 expression, VEGF expression, Collagen density, and clinical features [PDF]

Open Veterinary Journal
Background: The incidence of wound complications after breast cancer surgery is > 30%. Delayed wound healing increases the risk of systemic recurrence up to three-fold after excisional surgery for primary breast cancer. Patients with breast malignant
Nike Sari Oktavia, Arifa Mustika, Afif Nurul Hidayati   +2 more
doaj   +2 more sources

Collagen density promotes mammary tumor initiation and progression [PDF]

BMC Medicine, 2008
Background Mammographically dense breast tissue is one of the greatest risk factors for developing breast carcinoma. Despite the strong clinical correlation, breast density has not been causally linked to tumorigenesis, largely because no animal model ...
Knittel Justin G, Eliceiri Kevin W, Inman David R, Provenzano Paolo P, Yan Long, Rueden Curtis T, White John G, Keely Patricia J   +7 more
doaj   +3 more sources