Results 11 to 20 of about 2,942,836 (290)

Collagen Density Modulates the Immunosuppressive Functions of Macrophages [PDF]

The Journal of Immunology, 2020
Abstract Tumor-associated macrophages (TAMs) support tumor growth by suppressing the activity of tumor-infiltrating T cells. Consistently, TAMs are considered a major limitation for the efficacy of cancer immunotherapy. However, the molecular reason behind the acquisition of an immunosuppressive TAM phenotype is not fully clarified ...
Anne Mette H Larsen, Dorota E Kuczek, Adrija Kalvisa, Majken S Siersbæk, Marie-Louise Thorseth, Astrid Z Johansen, Marco Carretta, Lars Grøntved, Ole Vang, Daniel H Madsen   +9 more
openaire   +4 more sources

Low Density Lipoproteins Modulate Collagen Metabolism in Fibroblasts

Journal of Cardiovascular Pharmacology and Therapeutics, 2003
High levels of low-density lipoprotein are associated with atherosclerosis, and myocardial and arterial remodeling. We postulated that low-density lipoprotein influences collagen synthesis and degradation in fibroblasts as a potential mechanism of tissue remodeling. Incubation of cultured human skin fibroblasts with low-density lipoproteins resulted in
Jacob Joseph, Jawahar L Mehta, Subramanian Ranganathan   +2 more
exaly   +3 more sources

Collagen Matrix Density Drives the Metabolic Shift in Breast Cancer Cells

EBioMedicine, 2016
Increased breast density attributed to collagen I deposition is associated with a 4–6 fold increased risk of developing breast cancer. Here, we assessed cellular metabolic reprogramming of mammary carcinoma cells in response to increased collagen matrix ...
Brett A. Morris, Brian Burkel, Suzanne M. Ponik, Jing Fan, John S. Condeelis, Julio A. Aguire-Ghiso, James Castracane, John M. Denu, Patricia J. Keely   +8 more
doaj   +3 more sources

Dual-energy computed tomography collagen density mapping of the temporomandibular disc [PDF]

BMC Medical Imaging
Background The aim of this study was to evaluate the feasibility of dual-energy computed tomography (DECT)-derived collagen density mapping of the temporomandibular disc and to analyze the association with CT-detected joint degeneration and clinically ...
Sevtap Tugce Ulas, Thomas Matthias Wittig, Virginie Kreutzinger, Friedemann Göhler, Erin C. Argentieri, Torsten Diekhoff, Katharina Ziegeler   +6 more
doaj   +2 more sources

Nonenzymatic Glycosylation Products on Collagen Covalently Trap Low-Density Lipoprotein [PDF]

Diabetes, 1985
Advanced nonenzymatic glycosylation products capable of cross-linking proteins accumulate on collagen in vivo in proportion to time-averaged blood glucose concentration. In this report, we have evaluated the ability of advanced nonenzymatic glycosylation productsformed on collagen in vitro to covalently bind low-density lipoprotein (LDL) in a manner ...
H Vlassara, M Brownlee
exaly   +3 more sources

CHA-collagen implantation to increase alveolar bone density

Majalah Kedokteran Gigi Indonesia, 2021
Tooth extraction is the common procedure in dentistry. This procedure causes a wound in teeth socket. Thus, the socket had to be secured to prevent over resorption of alveolar bone.
Dody Setiawan, Poerwati Soetji Rahajoe, Cahya Yustisia Hasan   +2 more
doaj   +3 more sources

Hypoxic Tumor Microenvironments Reduce Collagen I Fiber Density

Neoplasia: An International Journal for Oncology Research, 2010
Although the mechanisms through which hypoxia influences several phenotypic characteristics such as angiogenesis, selection for resistance to apoptosis, resistance to radiation and chemotherapy, and increased invasion and metastasis are well ...
Samata M. Kakkad, Meiyappan Solaiyappan, Brian O’Rourke, Ioannis Stasinopoulos, Ellen Ackerstaff, Venu Raman, Zaver M. Bhujwalla, Kristine Glunde   +7 more
doaj   +3 more sources

Collagen density regulates xenobiotic and hypoxic response of mammary epithelial cells [PDF]

Environmental Toxicology and Pharmacology, 2015
Breast density, where collagen I is the dominant component, is a significant breast cancer risk factor. Cell surface integrins interact with collagen, activate focal adhesion kinase (FAK), and downstream cell signals associated with xenobiotics (AhR, ARNT) and hypoxia (HIF-1α, ARNT).
Colleen Curran, Suzanne Ponik, Patricia J Keely   +2 more
exaly   +3 more sources

The Effectiveness of Sungkai Leaf (Peronema canescens Jack.) Extract Gel on the Collagen Density of Incision Wounds in Vivo

Majalah Obat Tradisional, 2023
An incision is an open wound resulting in skin injury and underlying tissues. The wound-healing process involves a proliferative phase that produces collagen.
Clarissa Ester Diana Putri, Herlina Eka Shinta, Fatmaria Fatmaria, Elsa Trinovita   +3 more
doaj   +1 more source

3D Cancer Models: The Need for a Complex Stroma, Compartmentalization and Stiffness

Frontiers in Bioengineering and Biotechnology, 2021
The use of tissue-engineered 3D models of cancer has grown in popularity with recent advances in the field of cancer research. 3D models are inherently more biomimetic compared to 2D cell monolayers cultured on tissue-culture plastic.
Judith Pape, Mark Emberton, Umber Cheema
doaj   +1 more source