Identifying nonalcoholic fatty liver disease patients with active fibrosis by measuring extracellular matrix remodeling rates in tissue and blood. [PDF]
, 2016 Excess collagen synthesis (fibrogenesis) in the liver plays a causal role in the progression of nonalcoholic fatty liver disease (NAFLD). Methods are needed to identify patients with more rapidly progressing disease and to demonstrate early response to ...
Angel, Thomas E +16 more
core +1 more source
Chemical chaperone treatment reduces intracellular accumulation of mutant collagen IV and ameliorates the cellular phenotype of a COL4A2 mutation that causes haemorrhagic stroke [PDF]
, 2013 Haemorrhagic stroke accounts for approximately 20% of stroke cases and porencephaly is a clinical consequence of perinatal cerebral haemorrhaging. Here we report the identification of a novel dominant G702D mutation in the collagen domain of COL4A2 ...
Aislynn Taggart +35 more
core +1 more source
Collagens and collagen-related diseases
Annals of Medicine, 2001 The collagen superfamily of proteins plays a dominant role in maintaining the integrity of various tissues and also has a number of other important functions. The superfamily now includes more than 20 collagen types with altogether at least 38 distinct polypeptide chains, and more than 15 additional proteins that have collagen-like domains.
Kari I. Kivirikko, Johanna Myllyharju
openaire +3 more sources
Recent Developments in Osteogenesis Imperfecta [PDF]
, 2015 Osteogenesis imperfecta (OI) is an uncommon genetic bone disease associated with brittle bones and fractures in children and adults. Although OI is most commonly associated with mutations of the genes for type I collagen, many other genes (some ...
Albert, Carolyne +3 more
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ADAM15 modulates outside-in signalling in chondrocyte–matrix interactions [PDF]
, 2008 ADAM15 belongs to a family of transmembrane multi-domain proteins implicated in proteolysis, cell–cell and cell–matrix interactions in various disease conditions.
Burkhardt, Harald +2 more
core +1 more source
Teflon Injection into the Trachea Causes Predictable Fibroblastic Response and Collagen Deposition: A Pilot Study. [PDF]
, 2016 BackgroundExpiratory central airway collapse is an increasingly recognized abnormality of the central airways and may be present in as many as 22% of patients evaluated for chronic obstructive pulmonary disease and/or asthma.
Baxter +28 more
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Multimodal optical characterisation of collagen photodegradation by femtosecond infrared laser ablation. [PDF]
, 2014 Collagen is a structural component of the human body, as a connective tissue it can become altered as a result of pathophysiological conditions. Although the collagen degradation mechanism is not fully understood, it plays an important role in ageing ...
Bozec, L +6 more
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Fibrotic and Vascular Remodelling of Colonic Wall in Patients with Active Ulcerative Colitis [PDF]
, 2016 open16noIntestinal fibrosis is a complication of inflammatory bowel disease [IBD]. Although fibrostenosis is a rare event in ulcerative colitis [UC], there is evidence that a fibrotic rearrangement of the colon occurs in the later stages.
Bassotti, Gabrio +15 more
core +2 more sources
Urinary proteomics can define distinct diagnostic inflammatory arthritis subgroups [PDF]
, 2017 Current diagnostic tests applied to inflammatory arthritis lack the necessary specificity to appropriately categorise patients. There is a need for novel approaches to classify patients with these conditions.
Gaya, Daniel +9 more
core +6 more sources
Discerning the spatio-temporal disease patterns of surgically induced OA mouse models [PDF]
, 2019 Osteoarthritis (OA) is the most common cause of disability in ageing societies, with no effective therapies available to date. Two preclinical models are widely used to validate novel OA interventions (MCL-MM and DMM).
Becker, Jessica +8 more
core +3 more sources