Results 101 to 110 of about 9,847,525 (326)

Genetic partitioning of interleukin-6 signalling in mice dissociates Stat3 from Smad3-mediated lung fibrosis [PDF]

, 2012
Idiopathic pulmonary fibrosis (IPF) is a fatal disease that is unresponsive to current therapies and characterized by excessive collagen deposition and subsequent fibrosis.
Anderson, G.P., Bozinovski, S., Ernst, M.R., Jarnicki, A.G., Jones, J., Knight, D.A., Lau, H.L., Laurent, G.J., McAnulty, R.J., McKenzie, B.S., Mutsaers, S.E., O'Donoghue, R.J.J., Prêle, C.M., Richards, C.D., Rose-John, S., Stumbles, P.A., Thiem, S., Vlahos, R., Wang, B., Zhu, H.J.   +19 more
core   +2 more sources

The role of nailfold capillaroscopy in interstitial lung diseases - Can it differentiate idiopathic cases from collagen tissue disease associated interstitial lung diseases? [PDF]

, 2015
Introduction: Nailfold capillaroscopy (NFC) is a non-invasive diagnostic test that is mostly used for early diagnosis of collagen tissue diseases (CTDs). We aimed to evaluate whether NFC findings could be a clue for discriminating idiopathic interstitial
Altınışık, Göksel, Balkarli, A., Çakmakçi Karadoğan, D., Çobankara, Veli, Önal, Özgür   +4 more
core   +1 more source

Evaluation of sweating responses in patients with collagen disease using the quantitative sudomotor axon reflex test (QSART): a study protocol for an investigator-initiated, prospective, observational clinical study. [PDF]

BMJ Open, 2021
Ashida M, Koga T, Morimoto S, Yozaki M, Ehara D, Koike Y, Murota H.   +6 more
europepmc   +1 more source

Relationship between serum transforming growth factor ß1 and liver collagen content in rats treated with carbon tetrachloride

Arquivos de Gastroenterologia, 2012
CONTEXT: Transforming Growth Factor ß1 (TGFß1) plays a fundamental role in fibrogenesis, although its importance as a biomarker of liver disease is still matter of debate.
Fernanda dos Santos Oliveira, Themis Reverbel da Silveira, Ursula Matte   +2 more
doaj   +1 more source

Mathematical modeling of collagen turnover in biological tissue [PDF]

, 2012
The final publication is available at Springer via http://dx.doi.org/10.1007/s00285-012-0613-yWe present a theoretical and computational model for collagen turnover in soft biological tissues. Driven by alterations in the mechanical environment, collagen
Kuhl, Ellen, Martínez, Miguel Àngel, Peña, Estefania, Sáez Viñas, Pablo   +3 more
core   +2 more sources

Disorder protects collagen networks from fracture [PDF]

arXiv, 2019
Collagen forms the structural scaffold of connective tissues in all mammals. Tissues are remarkably resistant against mechanical deformations because collagen molecules hierarchically self-assemble in fibrous networks that stiffen with increasing strain.
arxiv  

Role of growth factors in the pathogenesis of tissue fibrosis in systemic sclerosis. [PDF]

, 2010
The most severe clinical and pathologic manifestations of systemic sclerosis (SSc) are the result of a fibrotic process characterized by the excessive and often progressive deposition of collagen and other connective tissue macromolecules in skin and ...
Castro, Susan V., Jimenez, Sergio A., Piera-Velazquez, Sonsoles   +2 more
core   +2 more sources

Is there a role for vitamin C in preventing osteoporosis and fractures?:A review of the potential underlying mechanisms and current epidemiological evidence [PDF]

, 2014
Osteoporosis and related fractures are a major global health issue, but there are few preventative strategies. Previously reported associations between higher intakes of fruits and vegetables and skeletal health have been suggested to be partly ...
Ailsa A. Welch, Amy Jennings, Andrew R. Hart, Bates, Bates, Canoy, Drewnowski, Gottlieb, Henriette Finck, Hill, Hoffer, Kaptoge, Lanham-New, Myllyla, New, New, Otsuka, Pradel, Prynne, Sahni, Scrimshaw, Sowers, Tucker, Wolf   +23 more
core   +1 more source

Genome-wide screens identify SEL1L as an intracellular rheostat controlling collagen turnover

Nature Communications
Accumulating evidence has implicated impaired extracellular matrix (ECM) clearance as a key factor in fibrotic disease. Despite decades of research elucidating the effectors of ECM clearance, relatively little is understood regarding the upstream ...
Michael J. Podolsky, Benjamin Kheyfets, Monika Pandey, Afaq H. Beigh, Christopher D. Yang, Carlos O. Lizama, Ritwik Datta, Liangguang L. Lin, Zhihong Wang, Paul J. Wolters, Michael T. McManus, Ling Qi, Kamran Atabai   +12 more
doaj   +1 more source

Lysyl oxidases regulate fibrillar collagen remodelling in idiopathic pulmonary fibrosis

Disease Models & Mechanisms, 2017
Idiopathic pulmonary fibrosis (IPF) is a progressive scarring disease of the lung with few effective therapeutic options. Structural remodelling of the extracellular matrix [i.e. collagen cross-linking mediated by the lysyl oxidase (LO) family of enzymes
Gavin Tjin, Eric S. White, Alen Faiz, Delphine Sicard, Daniel J. Tschumperlin, Annabelle Mahar, Eleanor P. W. Kable, Janette K. Burgess   +7 more
doaj   +1 more source