Results 121 to 130 of about 10,231,394 (364)

A Vascular Microphysiological Model of Lung Fibrosis Reveals That Myofibroblasts and IPF Patient‐Derived Fibroblasts Impair Angiogenesis and Vasculogenesis

Advanced Functional Materials, EarlyView.
A microphysiological lung fibrosis model recapitulates myofibroblast–vascular interactions. Induced myofibroblasts and patient‐derived IPF fibroblasts impair angiogenesis and increase vascular permeability via TGF‐β1–driven signaling. Pharmacological interventions with SB 431542 and VEGF supplementation restore vascular morphology and barrier function.
Elena Cambria, Adriana Blazeski, Eunkyung Clare Ko, Tran Thai, Shania Dantes, David A. Barbie, Sarah E. Shelton, Roger D. Kamm   +7 more
wiley   +1 more source

Genome-wide screens identify SEL1L as an intracellular rheostat controlling collagen turnover

Nature Communications
Accumulating evidence has implicated impaired extracellular matrix (ECM) clearance as a key factor in fibrotic disease. Despite decades of research elucidating the effectors of ECM clearance, relatively little is understood regarding the upstream ...
Michael J. Podolsky, Benjamin Kheyfets, Monika Pandey, Afaq H. Beigh, Christopher D. Yang, Carlos O. Lizama, Ritwik Datta, Liangguang L. Lin, Zhihong Wang, Paul J. Wolters, Michael T. McManus, Ling Qi, Kamran Atabai   +12 more
doaj   +1 more source

A Smart Bio‐Battery Facilitates Diabetic Bone Defect Repair Via Inducing Macrophage Reprogramming and Synergistically Modulating Bone Remodeling Coupling

Advanced Functional Materials, EarlyView.
This research presents a novel implantable bio‐battery, GF‐OsG, tailored for diabetic bone repair. GF‐OsG generates microcurrents in high‐glucose conditions to enhance vascularization, shift macrophages to the M2 phenotype, and regulate immune responses.
Nanning Lv, Haifu Sun, Wenxiang Tang, Yonggang Li, Zhonglai Qian, Lihui Hong, Chong Chen, Hongye Li, Jiaxiang Bai, Yusen Qiao, Mingming Liu   +10 more
wiley   +1 more source

Passive transfer of collagen XVII-specific antibodies induces sustained blistering disease in adult mice

Orphanet Journal of Rare Diseases, 2013
Background Bullous pemphigoid is a subepidermal blistering disorder associated with tissue-bound and circulating autoantibodies directed mainly to the hemidesmosomal component collagen XVII.
Chiriac Mircea Teodor, Licarete Emilia, Sas Alexandra Gabriela, Rados Andreea Maria, Lupan Iulia, Chiriac Anca Mirela, Speth Hilda, Pop-Vancia Vlad, Domsa Iacob, Sesarman Alina, Popescu Octavian, Sitaru Cassian   +11 more
doaj   +1 more source

Region‐to‐Region Unidirectional Connection In Vitro Brain Model for Studying Directional Propagation of Neuropathologies

Advanced Functional Materials, EarlyView.
A unidirectional cerebral organoid–organoid neural circuit is established using a microfluidic platform, enabling controlled directional propagation of electrical signals, neuroinflammatory cues, and neurodegenerative disease–related proteins between spatially separated organoids.
Kyeong Seob Hwang, Hui‐Wen Liu, Hyogeun Shin, Hyun Wook Kang, Minjin Kang, Jongbaeg Kim, Il‐Joo Cho, Nakwon Choi, Seok Chung, Hong Nam Kim   +9 more
wiley   +1 more source

Exploring marine collagen: Sustainable sourcing, extraction methods, and cosmetic applications

South African Journal of Chemical Engineering
The predominant sources of collagen for cosmetic purposes were traditionally derived from bovine and porcine products, such as bones, tendons, and connective tissues.
Vicky Prajaputra, Nadia Isnaini, Siti Maryam, Ernawati Ernawati, Fitri Deliana, Haekal Azief Haridhi, Nur Fadli, Sofyatuddin Karina, Sri Agustina, Nurfadillah Nurfadillah, Iko Imelda Arisa, Lydia Septa Desiyana, Tedy Kurniawan Bakri   +12 more
doaj   +1 more source

Biallelic TANGO1 mutations cause a novel syndromal disease due to hampered cellular collagen secretion [PDF]

, 2019
Caroline Lekszas, Ombretta Foresti, Ishier Raote, Daniel Liedtke, Eva‐Maria König, Indrajit Nanda, Barbara Vona, Peter De Coster, Rita Cauwels, Vivek Malhotra, Thomas Haaf   +10 more
openalex   +1 more source

Upconversion Nanoparticles Embedded Photonic Contact Lens for Transepithelial Corneal Crosslinking Using Hyaluronate – Riboflavin Conjugate

Advanced Functional Materials, EarlyView.
A minimally invasive, transepithelial corneal cross‐linking (TE‐CXL) approach is presented using upconversion nanoparticles (UCNPs)‐loaded contact lenses (UCLs), after topical delivery of hyaluronate–riboflavin conjugates. The NIR‐to‐UV/blue light conversion by UCNPs in a UCL can activate riboflavin for TE‐CXL, resulting in the biomechanical strength ...
Gibum Lee, Inhoo Choi, Anara Molkenova, Yengwoo Son, Seungmin Yang, Mina Kwon, Tae‐Im Kim, Ki Su Kim, Sei Kwang Hahn   +8 more
wiley   +1 more source

Microplastics from Wearable Bioelectronic Devices: Sources, Risks, and Sustainable Solutions

Advanced Functional Materials, EarlyView.
Bioelectronic devices (e.g., e‐skins) heavily rely on polymers that at the end of their life cycle will generate microplastics. For research, a holistic approach to viewing the full impact of such devices cannot be overlooked. The potential for devices as sources for microplastics is raised, with mitigation strategies surrounding polysaccharide and ...
Conor S. Boland
wiley   +1 more source

Molecular and Mesoscale Mechanisms of Osteogenesis Imperfecta Disease in Collagen Fibrils [PDF]

, 2009
Alfonso Gautieri, Sebastien G. M. Uzel, Simone Vesentini, Alberto Redaelli, Markus J. Buehler   +4 more
openalex   +1 more source