Targeting inflammation with collagen
Clinical and Translational Medicine, 2022 Tissue damage caused by an infection or an autoimmune disease triggers degradation of collagen in the extracellular matrix (ECM), which further enhances inflammation.
Dennis Schwarz +3 more
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2023 Collagen XII, a fibril-associated collagen with interrupted triple helices (FACIT), influences fibrillogenesis in numerous tissues. In addition to this extracellular function, collagen XII also directly regulates cellular function. Collagen XII is widely
Yayoi Izu, David E. Birk
doaj +1 more source
Blood, 1955 1. A circulating anticoagulant was demonstrated in three patients with "collagen disease." In all cases it was associated with a false positive blood serology and a four plus cephalin cholesterol flocculation. 2.
P. Frick, M. Weimer
semanticscholar +1 more source
Assessment of tissue fibrosis in skin biopsies from patients with systemic sclerosis employing confocal laser scanning microscopy: an objective outcome measure for clinical trials? [PDF]
, 2010 OBJECTIVES: To obtain an objective, unbiased assessment of skin fibrosis in patients with SSc for use in clinical trials of SSc disease-modifying therapeutics.
Busquets, Joanna +3 more
core +3 more sources
A Role of Myocardin Related Transcription Factor-A (MRTF-A) in Scleroderma Related Fibrosis. [PDF]
, 2015 In scleroderma (systemic sclerosis, SSc), persistent activation of myofibroblast leads to severe skin and organ fibrosis resistant to therapy. Increased mechanical stiffness in the involved fibrotic tissues is a hallmark clinical feature and a cause of ...
Abraham, D +11 more
core +6 more sources
Cardiac lesions in collagen disease.
Japanese circulation journal, 1975 Clinical and pathological abnormalities of the heart that may have major functional significance in those conditions were studied in collagen disease (total 242 cases). 1.
T. Okada, Y. Shiokawa
semanticscholar +1 more source
Extracellular matrix remodeling and TGF-β1/Smad signaling in diabetic colon mucosa [PDF]
, 2017 Diabetes is associated with metabolic and functional alterations in the gut. Using an experimental model of streptozotocin (STZ)-induced diabetes in rodents, we analyzed the extracellular matrix (ECM) and TGF-β/Smad signaling in the colon mucosa.
D'arpino, María Cecilia +3 more
core +1 more source
Urine peptidomic biomarkers for diagnosis of patients with systematic lupus erythematosus [PDF]
, 2018 Background: Systematic lupus erythematosus (SLE) is characterized with various complications which can cause serious organ damage in the human body. Despite the significant improvements in disease management of SLE patients, the non-invasive diagnosis ...
Burkly, L.C. +6 more
core +1 more source
Pain pathogenesis in rheumatoid arthritis -- what have we learned from animal models [PDF]
PAIN 2018 Sep; 159 Suppl:S98-S109, 2019 Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by joint inflammation and joint pain. Much of RA treatment is focused on suppressing inflammation, with the idea being that if inflammation is controlled other symptoms, such as pain, will disappear. However, pain is the most common complaint of RA patients, is often still present
arxiv +1 more source
Does urinary peptide content differ between COPD patients with and without inherited alpha-1 antitrypsin deficiency? [PDF]
, 2017 Differentiating between chronic obstructive pulmonary disease (COPD) patients with normal (PiMM) or deficient (PiZZ) genetic variants of alpha-1 antitrypsin (A1AT) is important not only for understanding the pathobiology of disease progression but also ...
Carleo, Alfonso +7 more
core +2 more sources