Developing Regenerative Treatments for Developmental Defects, Injuries, and Diseases Using Extracellular Matrix Collagen-Targeting Peptides. [PDF]
, 2019 Collagen is the most widespread extracellular matrix (ECM) protein in the body and is important in maintaining the functionality of organs and tissues.
Goldbloom-Helzner, Leora +2 more
core +1 more source
A microstructural model of tendon failure [PDF]
arXiv, 2021 Collagen fibrils are the most important structural component of tendons. Their crimped structure and parallel arrangement within the tendon lead to a distinctive non-linear stress-strain curve when a tendon is stretched. Microstructural models can be used to relate microscale collagen fibril mechanics to macroscale tendon mechanics, allowing us to ...
arxiv
Disseminated eosinophilic collagen disease.
Blood, 1967 A patient with disseminated eosinophilic collagen disease as reported in the Scandanavian and European literature and perhaps described under various titles—such as eosinophilic leukemia, Loeffler’s syndrome, parietal endocarditis,16 and allergic ...
Lawrence E. Pierce +2 more
semanticscholar +1 more source
Biophysical and biomechanical properties of cartilage [PDF]
arXiv, 2023 Cartilage is a connective tissue that covers the surfaces of bones in joints and provides a smooth gliding surface for movement. It is characterized by specific biophysical properties that allow it to withstand compressive loads, distribute mechanical forces, and maintain tissue integrity.
arxiv
Stage-specific action of matrix metalloproteinases influences progressive hereditary kidney disease. [PDF]
, 2006 BackgroundGlomerular basement membrane (GBM), a key component of the blood-filtration apparatus in the in the kidney, is formed through assembly of type IV collagen with laminins, nidogen, and sulfated proteoglycans.
Cosgrove, Dominic +8 more
core +3 more sources
Nimesulide improves the symptomatic and disease modifying effects of leflunomide in collagen induced arthritis. [PDF]
PLoS ONE, 2014 Nimesulide is a COX-2 inhibitor used for symptomatic relief of rheumatoid arthritis. Leflunomide is an anti-pyrimidine used to manage the progression of rheumatoid arthritis.
Ahmed M Al-Abd +7 more
doaj +1 more source
Urinary peptidomics provides a noninvasive humanized readout of diabetic nephropathy in mice [PDF]
, 2016 Nephropathy is among the most frequent complications of diabetes and the leading cause of end-stage renal disease. Despite the success of novel drugs in animal models, the majority of the subsequent clinical trials employing those drugs targeting ...
Bascands, Jean-Loup +9 more
core +1 more source
Investigation of the role of endosomal Toll-like receptors in murine collagen-induced arthritis reveals a potential role for TLR7 in disease maintenance [PDF]
, 2012 INTRODUCTION Endosomal toll-like receptors (TLRs) have recently emerged as potential contributors to the inflammation observed in human and rodent models of rheumatoid arthritis (RA).
Alzabin, Saba +5 more
core +1 more source
Second-harmonic generation microscopy analysis reveals proteoglycan decorin is necessary for proper collagen organization in prostate. [PDF]
, 2019 Collagen remodeling occurs in many prostate pathologies; however, the underlying structural architecture in both normal and diseased prostatic tissues is largely unexplored.
Bushman, Wade A. +5 more
core +1 more source
Targeting the LOX/hypoxia axis reverses many of the features that make pancreatic cancer deadly: inhibition of LOX abrogates metastasis and enhances drug efficacy [PDF]
, 2015 Pancreatic ductal adenocarcinoma (PDAC) is one of the leading causes of cancer‐related mortality. Despite significant advances made in the treatment of other cancers, current chemotherapies offer little survival benefit in this disease ...
Amy Au +25 more
core +2 more sources