Results 61 to 70 of about 10,231,394 (364)

Structure-mechanics relationships of collagen fibrils in the Osteogenesis Imperfecta Mouse model [PDF]

, 2015
The collagen molecule, which is the building block of collagen fibrils, is a triple helix of two α1(I) chains and one α2(I) chain. However, in the severe mouse model of osteogenesis imperfecta (OIM), deletion of the COL1A2 gene results in the ...
Andriotis, OG, Buhler, MJ, Chang, SW, Davies, DE, Howarth, PH, Shefelbine, S, Thurner, PJ, Vanleene, M   +7 more
core   +4 more sources

Involvement of central airways in vibroacoustic disease patients Participação das vias aéreas centrais na doença vibroacústica

Revista Portuguesa de Pneumologia, 2006
Introduction. Vibroacoustic disease (VAD) is the whole-body pathology caused by excessive exposure to LFN. For the past 25 years, it has been know that low frequency noise (LFN,
José Reis Ferreira, Miguel B Monteiro, Fernanda Tavares, Isabel Serrano, Emanuel Monteiro, Carla P Mendes, Mariana Alves-Pereira, Nuno A A Castelo Branco   +7 more
doaj  

Chemical Tools for Monitoring and Targeting Collagen Cross-linking

CHIMIA
The formation of collagen, the most abundant protein in mammals, is vital for the integrity of skin, tendons, and tissue in essentially any organ. Excessive collagen formation is, however, characteristic of fibrotic and malignant diseases, which include ...
Matthew C. Deen, Linus B. Boll, Helma Wennemers   +2 more
doaj   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Urine peptidomic biomarkers for diagnosis of patients with systematic lupus erythematosus [PDF]

, 2018
Background: Systematic lupus erythematosus (SLE) is characterized with various complications which can cause serious organ damage in the human body. Despite the significant improvements in disease management of SLE patients, the non-invasive diagnosis ...
Burkly, L.C., Mischak, H., Mullen, W., Pejchinovski, M., Petri, M.A., Siwy, J., Wei, R.   +6 more
core   +1 more source

Refractory and Relapsing Laryngeal Edema Possibly Associated With Chronic Tonsillitis and Mycoplasma Infection, Requiring Reintubation and Tracheostomy

Case Reports in Medicine
Relapsing epiglottitis has rarely been reported, and its etiology is not well established. A 44-year-old previously healthy Japanese man presented with a quickly progressing choking sensation.
Yutaka Tsukamoto, Takashi Sugimoto, Masataka Umeda, Yuki Furuse, Haruo Yoshida, Yuka Nagae, Yasuo Ohsato, Yukitaka Ueki, Maeda Takahiro, Koya Ariyoshi   +9 more
doaj   +1 more source

Increasing extracellular matrix collagen level and MMP activity induces cyst development in polycystic kidney disease

BMC Nephrology, 2012
Background Polycystic Kidney Disease (PKD) kidneys exhibit increased extracellular matrix (ECM) collagen expression and metalloproteinases (MMPs) activity. We investigated the role of these increases on cystic disease progression in PKD kidneys.
Liu Bin, Li Chenghai, Liu Zijuan, Dai Zonghan, Tao Yunxia   +4 more
doaj   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

Targeting ROCK activity to disrupt and prime pancreatic cancer for chemotherapy [PDF]

, 2017
Pancreatic ductal adenocarcinoma (PDAC) is a devastating disease; the identification of novel targets and development of effective treatment strategies are urgently needed to improve patient outcomes.
Olson, Michael F., Pajic, Marina, Rath, Nicola, Timpson, Paul, Vennin, Claire   +4 more
core   +1 more source

Enhanced Dupuytren's disease fibroblast populated collagen lattice contraction is independent of endogenous active TGF-β₂

BMC Musculoskeletal Disorders, 2004
Background Dupuytren's disease (DD) is a debilitating fibro-proliferative disorder of the hand characterized by the appearance of fibrotic lesions (nodules and cords) leading to flexion contractures of the fingers and loss of hand function.
Howard Jeffrey, Tse Raymond, Wu Yan, Gan Bing   +3 more
doaj   +1 more source