Results 71 to 80 of about 10,231,394 (364)
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Mechanical behavior of osteoporotic bone at sub-lamellar length scales [PDF]
, 2015 Osteoporosis is a disease known to promote bone fragility but the effect on the mechanical properties of bone material, which is independent of geometric effects, is particularly unclear.
Anna eShipov +4 more
core +2 more sources
Indian Journal of Dental Research, 2007 Systemic sclerosis (scleroderma) is a rare generalized disorder of connective tissue origin. This condition is predominantly a clinical diagnosis, based on the clinical signs and symptoms.
Ahathya R, Deepalakshmi D, Emmadi Pamela
doaj
Frontiers in Bioengineering and BiotechnologyCollagen is the predominant structural protein, contributing to 25%–30% of total body protein. It is vital for maintaining the strength, flexibility, and structural integrity of connective tissues throughout the human body.
Hemalatha Kanniyappan +5 more
doaj +1 more source
Dermatosparaxis in two White Doper lambs in Brazil: case report
Arquivo Brasileiro de Medicina Veterinária e Zootecnia, 2015 Dermatosparaxis is a genetic disease that affects collagen maturation. This disease is characterized by marked impairment of the resistance of collagen fibers that leads to skin fragility, and it may affect several species.
A.P.C. Silva +4 more
doaj +1 more source
Collagen piezoelectricity in osteogenesis imperfecta and its role in intrafibrillar mineralization
Communications Biology, 2022 Piezoresponse force microscopy reveals abnormal piezoelectric and mechanical properties of collagen fibrils in brittle bone disease, highlighting the importance of collagen piezoelectricity in intrafibrillar mineralization.
Jinha Kwon, Hanna Cho
doaj +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Histone deacetylase inhibitors induce invasion of human melanoma cells in vitro via differential regulation of N-cadherin expression and RhoA activity [PDF]
, 2016 Background: Histone deacetylase inhibitors (HDACi) exert multiple cytotoxic actions on cancer cells. Currently, different synthetic HDACi are in clinical use or clinical trials; nevertheless, since both pro-invasive and anti-invasive activities have been
Andrade, Ricardo +6 more
core +4 more sources
Type XIX collagen: a promising biomarker from the basement membranes
Neural Regeneration Research, 2020 Among collagen members in the collagen superfamily, type XIX collagen has raised increasing interest in relation to its structural and biological roles.
Ana C Calvo +13 more
doaj +1 more source
Epidermolysis bullosa acquisita treated with ustekinumab: A case report
SAGE Open Medical Case Reports, 2022 Epidermolysis bullosa acquisita is a rare autoimmune disease involving cutaneous blistering and scarring associated with collagen VII autoantibodies.
Connor Prosty +4 more
doaj +1 more source