Results 111 to 120 of about 346,226 (309)
Collagen Injections for Rotator Cuff Diseases: A Systematic Review
Clinics and PracticeBackground: Because of its anatomy and function, the rotator cuff (RC) is vulnerable to considerable morbidity. The prevalence of RC diseases (RCDs) among the general population is 5–39%, reaching over 30% in patients older than 60.
Rocco Aicale +9 more
doaj +1 more source
The Role of Collagen Autoimmunity in Animal Models and Human Diseases
, 1982 Although immune reactions to collagen have been described in several diseases, the pathophysiologic consequences of collagen autoimmunity remain obscure. We have recently described an animal model of polyarthritis which can be induced in susceptible rats
Kang, Andrew H. +2 more
core +1 more source
Multidimensional Cellular Micro‐Compartments to Model Invasive Lobular Carcinoma Dormancy
Advanced Healthcare Materials, EarlyView.Invasive lobular carcinoma (ILC) is an understudied subtype of breast cancer that is susceptible to late recurrences. In this study, micro‐compartmentalization techniques spanning multiple dimensions, including 2D, pseudo‐3D, and 3D, are integrated to uncover the mechanisms underlying ILC dormancy, revealing the central role of p27Kip1.
Xilal Y. Rima +15 more
wiley +1 more source
Collagen remodelling in pulmonary diseases
, 2016 Fibrillar collagens act as biological scaffolds in every organ in the body. The amount of collagens are known to be altered in pulmonary diseases such as chronic obstructive pulmonary disease (COPD) and idiopathic pulmonary fibrosis (IPF) but the ...
Tjin, Gavin
core
Advanced Healthcare Materials, EarlyView.A human 3D bone niche integrating osteoblasts and osteoclasts enables co‐culture with prostate cancer cell lines and patient‐derived organoids. The engineered niche (i) models aspects of reciprocal phenotypic regulation between osteoblasts and cancer cells, (ii) captures osteoclast‐enhanced osteomimicry in tumor cells, and (iii) establishes a ...
Andrea Mazzoleni +7 more
wiley +1 more source
Disease modelling using evolved discriminate function
, 2003 Precocious diagnosis increases the survival time and patient quality of life. It is a binary classification, exhaustively studied in the literature. This paper innovates proposing the application of genetic programming to obtain a discriminate function ...
Werner, J C, Kalganova, T
core
Advanced Healthcare Materials, EarlyView.Spontaneous helical alignment of smooth muscle cells is induced within resistance‐vessel‐sized channels patterned within a hydrogel. The extent of the cells’ orientation angle is dependent on the presence and composition of ECM proteins lining the channel wall and cell seeding density.
Victoria D. Vest +5 more
wiley +1 more source
Advanced Healthcare Materials, EarlyView.This study investigates the M13 bacteriophage as a biomimetic nanovector capable of crossing in vitro models of the blood–brain barrier. By exploiting peculiar transcellular pathways, M13 avoids lysosomal degradation and preserves its structural integrity and functionality.
Silvia Vercellino +12 more
wiley +1 more source
HSP47 in human diseases: Navigating pathophysiology, diagnosis and therapy
Clinical and Translational MedicineHeat shock protein 47 (HSP47) is a chaperone protein responsible for regulating collagen maturation and transport, directly impacting collagen synthesis levels. Aberrant HSP47 expression or malfunction has been associated with collagen‐related disorders,
Essak. S. Khan, Tobias Däinghaus
doaj +1 more source
Лечащий ВрачBackground. Venous trophic ulcers are a typical manifestation of decompensation of chronic venous insufficiency of the lower extremities. The causes of venous trophic ulcers are chronic vein diseases such as varicose veins of the lower limbs, pelvis ...
A. V. Teplikov, A. I. Cherepanin
doaj +1 more source