Results 161 to 170 of about 288,861 (296)

Engineered MSC Aggregates with E/N‐Cadherin and IL‐6 Preconditioning for the Treatment of Systemic Sclerosis

Advanced Healthcare Materials, EarlyView.
Engineered 3D‐Cad/IL6‐MSC, developed through synergistic hE/N‐cad‐Fc and IL‐6 preconditioning, show remarkable therapeutic potential for systemic sclerosis. These engineered MSC aggregates reduce pathogenic inflammatory cell infiltration and restore immune balance among CD4+ T‐cell populations, offering a promising approach to optimize MSC based ...
Yue Zhang, Mengyuan Qian, Yirui Shi, Jiaxu Cao, Min Xu, Xin Wen, Yunxia Yan, Sha Liu, Hongwei Chen, Shanshan Liu, Jun Yang, Lingyun Sun   +11 more
wiley   +1 more source

Zhilong Huoxue Tongyu capsule inhibits hypertensive myocardial fibrosis via balancing TGF-β1/Smad3/Erbb4-IR/miR-29b pathway. [PDF]

Sci Rep
Liu Q, Zhang D, Wang R, Sun S, Li Y, Wan Z, Qian Y, Yang X, Luo G, Chen M, Liu M.   +10 more
europepmc   +1 more source

Renal biopsy collagen I mRNA predicts scarring in rabbit anti-GBM disease: Comparison with conventional measures

, 1997
Sang-Koo Lee, Meera Goyal, Mariano De Miguel, Peedikayil E. Thomas, Bryan L. Wharram, Robert C. Dysko, Sem H. Phan, Paul D. Killen, Roger C. Wiggins   +8 more
openalex   +1 more source

A Novel Sprayable Fibrinogen/Glycosaminoglycans/Collagen‐Based Bioink for Skin Wound Healing Applied by a Handheld Dual‐Head Airbrush

Advanced Healthcare Materials, EarlyView.
A dual‐head airbrush‐based spraying device, combined with a fibrinogen bioink enriched with glycosaminoglycans and collagen, enables the delivery of biomaterials and cells to promote wound healing. This system demonstrates effective skin regeneration in vitro and in vivo, with comparable results to autografts.
Paula Pleguezuelos‐Beltrán, Daniel Nieto‐García, Carlos Chocarro‐Wrona, Juan de Vicente, Patricia Gálvez‐Martín, José Manuel Entrena, Elena López‐Ruiz, Juan Antonio Marchal   +7 more
wiley   +1 more source

Conditioned Media from Mechanically Stimulated Macrophages Upregulate Osteogenic Genes in Human Mesenchymal Stromal Cells

Advanced Healthcare Materials, EarlyView.
Bone fracture healing is a complex, timely orchestrated scenario involving multiple cell types and a plethora of cytokines and regulatory factors. To gain further insight, an in vitro model to a) study macrophage polarization under mechanical load in a fibrin hydrogel and b) subsequently assess the effect of conditioned media derived from macrophages ...
Anne Géraldine Guex, Ursula Menzel, Yann Ladner, Angela R. Armiento, Martin J. Stoddart   +4 more
wiley   +1 more source

Synchrotron-based X-ray 3D phase contrast imaging and analysis of transmural myocardial tissue from heart failure patients. [PDF]

Sci Rep
Skreb N, Loncaric F, Li KYC, Bonnin A, Dejea H, Garcia-Canadilla P, Ilic I, Gasparovic H, Milicic D, Bijnens B, Cook AC, Planinc I, Cikes M.   +12 more
europepmc   +1 more source

Animal‐Free Setup of a 3D Mature Adipocyte‐Macrophage Co‐Culture to Induce Inflammation In Vitro

Advanced Healthcare Materials, EarlyView.
A completely animal‐free 3D co‐culture is developed using human fat cells and immune cells. Animal‐based materials are replaced with gellan gum hydrogel and a serum‐free medium. Immune cells are effectively activated, producing specific inflammatory signals.
Sophia Nowakowski, Svenja Nellinger, Franziska Brigitte Albrecht, Petra Juliane Kluger   +3 more
wiley   +1 more source

Collagen Type IV Variants and Kidney Cysts: Decoding the COL4A Puzzle. [PDF]

Genes (Basel)
Rigato M, Caprara C, Cabrera-Aguilar JS, Marzano N, Giuliani A, Mancini B, Gastaldon F, Ronco C, Zanella M, Zuccarello D, Corradi V.   +10 more
europepmc   +1 more source

Integration of Bioengineered Tools in Assisted Reproductive Technologies

Advanced Healthcare Materials, EarlyView.
A conceptual illustration depicting the collaboration between a medical professional (right) and a scientist (left). Their connection highlights the integration of scientific research and clinical practice. This representation underscores the role of emerging technologies in bridging fundamental research with applied reproductive healthcare.
Aslı Ak, Edith Coonen, Ron van Golde, Erik Vrij   +3 more
wiley   +1 more source

Autosomal recessive Bethlem myopathy: a 30-year journey. [PDF]

J Neurol
Gallone A, Riolo G, Ruggieri A, Iannibelli E, Salerno F, Nicolini De Gaetano L, Carnazzi A, Maggi L, Gibertini S.   +8 more
europepmc   +1 more source