Collagen Fibril Orientation Instructs Fibroblast Differentiation Via Cell Contractility [PDF]
Advanced Science, 2023 Collagen alignment is one of the key microarchitectural signatures of many pathological conditions, including scarring and fibrosis. Investigating how collagen alignment modulates cellular functions will pave the way for understanding tissue scarring and
Jiranuwat Sapudom +6 more
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Age-related changes in the quadriceps tendon: Collagen fibril diameter decreases with aging [PDF]
Asia-Pacific Journal of Sports Medicine, Arthroscopy, Rehabilitation and TechnologyBackground: The quadriceps tendon (QT) has recently gained attention as a graft tendon for anterior cruciate ligament (ACL) reconstruction due to its high strength from a larger ultrastructural collagen fibril diameter in children than that of the ...
Yoshihiro Ishida +8 more
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Decorin core protein (decoron) shape complements collagen fibril surface structure and mediates its binding. [PDF]
PLoS ONE, 2009 Decorin is the archetypal small leucine rich repeat proteoglycan of the vertebrate extracellular matrix (ECM). With its glycosaminoglycuronan chain, it is responsible for stabilizing inter-fibrillar organization. Type I collagen is the predominant member
Joseph P R O Orgel +4 more
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Cross‐sectional area on magnetic resonance images of the semitendinosus tendon is strongly related to the collagen fibril diameter [PDF]
Journal of Experimental OrthopaedicsPurpose Using a thin semitendinosus tendon as an autograft is a risk factor for poor clinical outcomes after anterior cruciate ligament reconstruction.
Yushin Mizuno +8 more
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Collagen fibril formation at the plasma membrane occurs independently from collagen secretion [version 1; peer review: 1 approved, 2 approved with reservations] [PDF]
Wellcome Open ResearchBackground Collagen fibrils are the primary supporting scaffolds of vertebrate tissues, but the mechanism of assembly is unclear. Methods Here, using CRISPR-tagging of type I collagen, high-resolution light imaging, and SILAC labelling, we elucidated the
Christina E. Hayward +14 more
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Coordinate roles for collagen VI and biglycan in regulating tendon collagen fibril structure and function [PDF]
Matrix Biology Plus, 2022 Tendon is a vital musculoskeletal tissue that is prone to degeneration. Proper tendon maintenance requires complex interactions between extracellular matrix components that remain poorly understood.
Ryan J. Leiphart +10 more
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Collagen Fibril Orientation in Tissue Specimens From Atherosclerotic Plaque Explored Using Small Angle X-Ray Scattering. [PDF]
J Biomech Eng, 2022 Silva H +5 more
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In tendons, differing physiological requirements lead to distinct patterns of MMP-1 degradation [PDF]
Scientific ReportsCollagen fibrils from high-stress, energy-storing tendons critical to locomotion are smaller in diameter with increased intermolecular crosslinking compared to fibrils from low-stress, positional tendons.
Kelsey Y. Gsell +2 more
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Regulatory properties of vitronectin and its glycosylation in collagen fibril formation and collagen-degrading enzyme cathepsin K activity. [PDF]
Sci Rep, 2021 Date K, Sakagami H, Yura K.
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Impact of Ultrasonication on the Self-Assembly Behavior and Gel Properties of Bovine Bone Collagen I
Molecules, 2023 This study deliberated the effect of ultrasonic treatment on collagen self-assembly behavior and collagen fibril gel properties. Bovine bone collagen I which had undergone ultrasonic treatment with different power (0–400 W) and duration (0–60 min) was ...
Hong Liu +6 more
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