Results 231 to 240 of about 23,427 (258)

Liver Stiffness Rises Early in MASLD and Drives Inflammation, Lipid Dysmetabolism, and Fibrosis via Piezo1–YAP Mechanotransduction

open access: yesAdvanced Science, EarlyView.
Progressive stiffening of the hepatic extracellular matrix and free fatty acid overload activate the mechanosensor Piezo1 in steatotic hepatocytes, inducing calcium influx and nuclear translocation of Yes‐associated protein. YAP‐dependent nuclear signaling further drives inflammatory and fibrotic gene programs, lipid metabolic reprogramming, and ...
Juan Ma   +15 more
wiley   +1 more source

Spatial Transcriptomics of TMJ Reveals a Remodeling Fibroblast‐Immune Microenvironment Driving Arthritis Pain

open access: yesAdvanced Science, EarlyView.
Spatial transcriptomics reveals a remodeled fibroblast‐immune microenvironment in the temporomandibular joint (TMJ) during arthritis. By combining seqFISH with genetic mouse models, this study uncovers TMJ spatial cell atalas, macrophage‐fibroblast crosstalk, and cytokine signaling pathways driving TMJ inflammation and pain.
Ziying Lin   +10 more
wiley   +1 more source

Creating Cell‐Based Hybrid Noodles for Sustainable and Nutrient‐Balanced Diets via a Serum‐Free and Animal‐Free 3D Co‐Differentiation System

open access: yesAdvanced Science, EarlyView.
This study develops a 3D co‐culture and co‐differentiation system for porcine muscle stem cells (pMuSCs) and mesenchymal stem cells (pMSCs) on edible starch‐based scaffolds. The system simultaneously generates myotubes and adipocytes without using serum or chemical inducers.
Xin Guan   +9 more
wiley   +1 more source

EGaIn‐Activated Bioinspired Silk Micro/Nanofibril Eutectogels Breaking the Strength–Conductivity Trade‐Off for High‐Performance Wearable Bioelectronics

open access: yesAdvanced Science, EarlyView.
Inspired by the extracellular matrix, eutectogels are prepared by in situ deconstruction of silk fibroin into micro/nanofibrils and EGaIn‐induced polymerization. The multiscale fibril network with dynamic crosslinking achieves high strength (1.25 MPa), toughness (23.09 MJ m−3), and conductivity (1.51 S m−1), outperforming previous natural polymer ...
Haiwei Yang   +4 more
wiley   +1 more source

Photoacoustic Microscopy for Multiscale Biological System Visualization and Clinical Translation

open access: yesAdvanced Science, EarlyView.
Photoacoustic microscopy (PAM) is a powerful biomedical imaging tool renowned for its non‐invasiveness and high resolution. This review synthesizes recent technological advances and highlights their broad applications from cellular and organ‐level to whole‐animal imaging.
Tingting Wang   +3 more
wiley   +1 more source

Refractive Index Mapping below the Diffraction Limit via Single Molecule Localization Microscopy. [PDF]

open access: yesACS Nano
Jaritz S   +9 more
europepmc   +1 more source

A 19% efficient and stable organic photovoltaic device enabled by a guest nonfullerene acceptor with fibril-like morphology

Energy and Environmental Science, 2023
Dipti R Naphade   +2 more
exaly  

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