Results 281 to 290 of about 23,206 (306)

Formation and Structure of the Collagen Fibril

Nature, 1963
IT seems to be generally assumed that collagen fibrils are solid structures, formed by the aggregation of large numbers of long, extremely thin, particles of tropocollagen1. However, during an investigation into collagen formation in the avascular granulomas produced on the surface of peritoneal implants of egg-white and agar2, the collagen fibrils ...
R. C. Curran, A. E. Clark
openaire   +3 more sources

DNA as a matrix of collagen fibrils

International Journal of Biological Macromolecules, 2005
In this paper we demonstrate that DNA binds to collagen directly to form DNA-collagen complex. Our model suggests that DNA, containing well-arranged phosphate groups, helps the collagen to make ordered aggregates-fibrils. During this process hydration shell of collagen triple helix destroys and stabilizes hydration shell of ds-DNA.
David V. Svintradze, G. M. Mrevlishvili
openaire   +3 more sources

Interaction of fibronectin with collagen fibrils

Biochemistry, 1981
The interaction of fibronectin with native collagen during collagen fibril formation was investigated. Fibronectin prepared from serum, or from the cell surface, bound to the forming collagen fibrils while less fibronectin bound to preformed fibers. Denatured collagen competed with native collagen in binding fibronectin.
Charlotte M. Wilkes, Hynda K. Kleinman, George R. Martin   +2 more
openaire   +2 more sources

Immunoelectronmicroscopical Investigations on Isolated Collagen Fibrils [PDF]

Albrecht von Graefes Archiv f�r Klinische und Experimentelle Ophthalmologie, 1980
Isolated collagen fibrils treated with type-specific antibodies can be stained using a peroxidase-antibody complex. The staining pattern of the fibrils with this peroxidase-antibody complex is demonstrated and compared with the normal negative staining pattern of the fibrils.
H. J. Barrach, J. P. Harnisch, P. K. Sinha   +2 more
openaire   +2 more sources

The Structure of Collagen Fibrils

1952
Publisher Summary This chapter discusses the available information, concerning collagen and featuring in particular X-ray diffraction, electron optics and certain phases of chemical evidence developed, covering the characterization of various members of the collagen class of fibrous protein and a derivation of the principal structural features of the
openaire   +3 more sources

Proteolysis of the collagen fibril in osteoarthritis

Biochemical Society Symposia, 2003
The development of cartilage pathology in osteoarthritis involves excessive damage to the collagen fibrillar network, which appears to be mediated primarily by the chondrocyte-generated cytokines interleukin-1 and tumour necrosis factor α and the collagenases matrix metalloproteinase-1 (MMP-1) and MMP-13.
R. Clark Billinghurst, Ginette R. Squires, Masahiko Kobayashi, Fred Nelson, Toshihisa Kojima, Tadashi Yasuda, Elena V. Tchetina, Sheila Laverty, Sheila Laverty, William Wu, A. Robin Poole, Leif Dahlberg   +11 more
openaire   +2 more sources

Visualizing collagen fibril growth

Journal of Molecular Graphics, 1994
Collagen fibrils are among the most abundant protein polymers in living organisms. While the longitudinal packing of molecules in the fibrils has been agreed on for many years, there is continuous disagreement over the lateral packing. In this work, we describe a set of computer graphics programs that can be used to visualize fibril packing and ...
John C. Miller, Deborah Silver
openaire   +3 more sources

Collagens, Suprastructures, and Collagen Fibril Assembly

2010
Extracellular matrices are composed of collagens, proteoglycans, glycosaminoglycans, glycoproteins, and elastin. Extracellular matrix not only serves as structural scaffolds in organs and tissues, but also determines cellular function through cell–matrix interactions.
David E. Birk, Peter Brückner
openaire   +2 more sources

The Structure of Mineralized Collagen Fibrils

Connective Tissue Research, 1989
A new model for the structure of mineralized bone collagen is presented which is compatible with neutron diffraction, electromicroscopic, crosslinking, and composition-density data. Mineralized collagen fibrils are comprised of azimuthally oriented, flexible molecules laterally arranged on a superlattice.
Mitsuo Yamauchi, E. P. Katz, E. Wachtel, Gerald L. Mechanic   +3 more
openaire   +3 more sources

Collagen Fibril Form and Function

2005
The majority of collagen in the extracellular matrix is found in a fibrillar form, with long slender filaments each displaying a characteristic approximately 67?nm D-repeat. Here they provide the stiff resilient part of many tissues, where the inherent strength of the collagen triple helix is translated through a number of hierarchical levels to endow ...
openaire   +4 more sources