Advanced glycation end-products reduce collagen molecular sliding to affect collagen fibril damage mechanisms but not stiffness. [PDF]
PLoS ONE, 2014 Advanced glycation end-products (AGE) contribute to age-related connective tissue damage and functional deficit. The documented association between AGE formation on collagens and the correlated progressive stiffening of tissues has widely been presumed ...
Gion Fessel +7 more
doaj +1 more source
D-band strain underestimates fibril strain for twisted collagen fibrils at low strains [PDF]
, 2021 Collagen fibrils are the main structural component of load-bearing tissues such as tendons, ligaments, skin, the cornea of the eye, and the heart. The D-band of collagen fibrils is an axial periodic density modulation that can be easily characterized by tissue-level X-ray scattering. During mechanical testing, D-band strain is often used as a proxy for
arxiv +1 more source
Thermal Destabilization of Collagen Matrix Hierarchical Structure by Freeze/Thaw. [PDF]
PLoS ONE, 2016 This study aims to characterize and understand the effects of freezing on collagen structures and functionality. Specifically, thermodynamic destabilization of collagen at molecular- and fibril-levels by combination of low temperatures and freezing were ...
Altug Ozcelikkale, Bumsoo Han
doaj +1 more source
Collagen Fibril Orientation Instructs Fibroblast Differentiation Via Cell Contractility
Advanced Science, 2023 Collagen alignment is one of the key microarchitectural signatures of many pathological conditions, including scarring and fibrosis. Investigating how collagen alignment modulates cellular functions will pave the way for understanding tissue scarring and
Jiranuwat Sapudom +6 more
doaj +1 more source
Understanding the viscoelastic behavior of collagen matrices through relaxation time distribution spectrum [PDF]
, 2013 This study aims to provide understanding of the macroscopic viscoelastic behavior of collagen matrices through studying the relaxation time distribution spectrum obtained from stress relaxation tests.
Li, Haiyue, Xu, Bin, Zhang, Yanhang
core +1 more source
PLoS ONE, 2020 Opticin is a class III member of the extracellular matrix small leucine-rich repeat protein/proteoglycan (SLRP) family found in vitreous humour and cartilage.
Uwe Hansen +3 more
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Multiscale Modeling of Collagen Fibril in Bone at Various Crosslink Densities: An Insight into Its Deformation Mechanisms [PDF]
, 2014 Multiscale modeling of collagen fibril is carried out by incorporating the material properties of collagen obtained from steered molecular dynamics into the finite element model of collagen fibril with inclusion of crosslinks.
D.R. Katti, K.S.Katti, S.M. Pradhan
core +2 more sources
Molecular origin of viscoelasticity in mineralized collagen fibrils [PDF]
Biomaterials Science, 9(9), 3390-3400 (2021), 2021 Bone is mineralized tissue constituting the skeletal system, supporting and protecting body organs and tissues. At the molecular level, mineralized collagen fibril is the basic building block of bone tissue, and hence, understanding bone properties down to fundamental tissue structures enables to better identify the mechanisms of structural failures ...
arxiv +1 more source
Revealing Accessibility of Cryptic Protein Binding Sites within the Functional Collagen Fibril
Biomolecules, 2017 Fibrillar collagens are the most abundant proteins in the extracellular matrix. Not only do they provide structural integrity to all of the connective tissues in the human body, but also their interactions with multiple cell receptors and other matrix ...
Cody L. Hoop +4 more
doaj +1 more source
Uniform spatial distribution of collagen fibril radii within tendon implies local activation of pC-collagen at individual fibrils [PDF]
Physical Biology, v. 13 (2016) 046008, 2016 Collagen fibril cross-sectional radii show no systematic variation between the interior and the periphery of fibril bundles, indicating an effectively constant rate of collagen incorporation into fibrils throughout the bundle. Such spatially homogeneous incorporation constrains the extracellular diffusion of collagen precursors from sources at the ...
arxiv +1 more source