Collagen XII, a fibril-associated collagen with interrupted triple helices (FACIT), influences fibrillogenesis in numerous tissues. In addition to this extracellular function, collagen XII also directly regulates cellular function. Collagen XII is widely
Yayoi Izu, David E. Birk
doaj +1 more source
Heterogeneous structure and dynamics of water in a hydrated collagen microfibril [PDF]
Collagen type I is well-known for its outstanding mechanical properties which it inherits from its hierarchical structure. Collagen type I fibrils may be viewed as an heterogeneous material made of protein, macromolecules (such as glycosaminoglycans and proteoglycans) and water. Water content modulates the properties of these heterofibrils.
arxiv
The structure and performance of collagen biomaterials : a thesis presented in partial fulfilment of the requirements for the degree of Doctor of Philosophy in Engineering, Massey University, Palmerston North, New Zealand [PDF]
Type I collagen materials are used in a wide range of industrial applications. Some examples include leather for shoes and upholstery, acellular dermal matrix (ADM) materials for surgical applications, and bovine pericardium for the fabrication of ...
Wells, Hannah
core
Current and Future Cornea Chip Models for Advancing Ophthalmic Research and Therapeutics
This review analyzes cornea chip technology as an innovative solution to corneal blindness and tissue scarcity. The examination encompasses recent developments in biomaterial design and fabrication methods replicating corneal architecture, highlighting applications in drug screening and disease modeling while addressing key challenges in mimicking ...
Minju Kim+3 more
wiley +1 more source
P136 ALTERED ADVENTITIAL COLLAGEN FIBRIL MECHANICS AND MORPHOLOGY WITH HIGH PULSE WAVE VELOCITY
Background: Arterial stiffening, occurring as part of the natural aging process of the artery, is well- established as a powerful predictor of cardiovascular disease.
Zhuo Chang+3 more
doaj +1 more source
The influence of AGEs and enzymatic cross-links on the mechanical properties of collagen fibrils [PDF]
Cross-links are considered to be a key component of collagen fibrils as they can change the fibrillar behavior in various ways. Advanced-Glycation Endproducts (AGEs), one particular type of cross-links, have been shown to accumulate and impair the mechanical properties of collageneous tissues, whereas enzymatic cross-links (ECLs) are known for ...
arxiv
Confined compression of collagen hydrogels [PDF]
Reconstituted collagen hydrogels are often used for in vitro studies of cell-matrix interaction and as scaffolds for tissue engineering. Understanding the mechanical and transport behaviours of collagen hydrogels is therefore extremely important, albeit ...
Busby, Grahame A.+3 more
core +1 more source
Bridging Nature and Technology: A Perspective on Role of Machine Learning in Bioinspired Ceramics
Machine learning (ML) is revolutionizing the development of bioinspired ceramics. This article investigates how ML can be used to design new ceramic materials with exceptional performance, inspired by the structures found in nature. The research highlights how ML can predict material properties, optimize designs, and create advanced models to unlock a ...
Hamidreza Yazdani Sarvestani+2 more
wiley +1 more source
Matrix metalloproteinase 14 is required for fibrous tissue expansion
Type I collagen-containing fibrils are major structural components of the extracellular matrix of vertebrate tissues, especially tendon, but how they are formed is not fully understood.
Susan H Taylor+10 more
doaj +1 more source
During embryonic development, tendons transform into a hypocellular tissue with robust tensile load-bearing capabilities. Previous work suggests that this mechanical transformation is due to increases in collagen fibril length and is dependent on ...
Benjamin E. Peterson+5 more
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