Results 271 to 280 of about 646,289 (307)
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Synthetic Collagen Heterotrimers: Structural Mimics of Wild-Type and Mutant Collagen Type I
Journal of the American Chemical Society, 2008Collagen type I is an AAB heterotrimer assembled from two alpha1 chains and one alpha2 chain. Missense mutations in either of these chains that substitute a glycine residue in the ubiquitous X-Y-Gly repeat with a bulky amino acid leads to osteogenesis imperfecta (OI) of varying severity. These mutations have been studied in the past using collagen-like
Varun, Gauba, Jeffrey D, Hartgerink
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Distribution of type I collagen in human kidney diseases in comparison with type III collagen
The Journal of Pathology, 1990AbstractThe distribution of type I collagen in normal and diseased renal tissues was studied using immunofluorescence and immunoelectron microscopy, and was compared with that of type III collagen. In normal human kidneys, a monoclonal antibody against type I or type III collagen reacted with the renal interstitium, but not with the intra‐glomerular ...
K, Yoshioka +6 more
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Interaction of Type I Collagen with Phosphatidylcholine Vesicles
Collagen and Related Research, 1988Type I collagen interacts with phosphatidylcholine vesicles. This conclusion has been obtained after ultracentrifugation, fluorescence polarization, circular dichroism and differential scanning calorimetry studies. The protein conformation is not modified by the presence of phospholipids.
A, Martinez del Pozo +3 more
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Binding of type-I collagen to Chlamydia trachomatis
Microbial Pathogenesis, 1994Denatured type-I collagen was found to bind to Chlamydia trachomatis elementary bodies (EBs) in a time-dependent and specific manner. Specificity was tested by having a large excess of other proteins present in the binding mixture. Only denatured type-I collagen efficiently competed for binding.
G, Fröman +3 more
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Antibody to Collagen Type I in Periodontal Disease
Journal of Periodontology, 1986Serum antibody levels to human collagen Type I were measured in 97 patients with periodontal disease (Russell Periodontal Index 1.0–7.0) and 57 control subjects (Periodontal Index <1.0) using an enzyme‐linked immunosorbent assay, which had been standardized with antisera prepared against human collagen Type I in rabbits. Absorption studies were used
A, Ftis, G, Singh, A E, Dolby
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Studies of type I collagen in osteogenesis imperfecta
The Journal of Pediatrics, 1990We used the results of skin fibroblast type I collagen analysis to improve the accuracy of diagnosis and genetic counseling for six patients with osteogenesis imperfecta. The fibroblasts of two patients with osteogenesis imperfecta type I synthesized a reduced quantity of qualitatively normal type I procollagen.
M J, Edwards, J M, Graham
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Fibromodulin Interactions with Type I and II Collagens
Connective Tissue Research, 2007Fibromodulin is a keratan-sulfate small leucine-rich proteoglycan (SLRP) regulating collagen I and II fibril formation. In vivo studies suggest that, alongside decorin, fibromodulin plays an important role in the maintenance of mature tissues. To characterize fibromodulin/decorin differences in binding to type I and II collagen, we tested the collagen ...
VIOLA, MANUELA +5 more
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Halofuginone: An inhibitor of collagen type I synthesis
Biochimica et Biophysica Acta (BBA) - General Subjects, 1993The effect of halofuginone--a plant alkaloid used as a coccidiostat in birds--on collagen metabolism was studied in various avian and mammalian cell cultures. In avian skin fibroblasts halofuginone attenuated the incorporation of [3H]proline into collagenase-digestible proteins (CDP) at concentrations as low as 10(-11) M, without affecting production ...
I, Granot +3 more
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Regulation of Type I Collagen Genes Expression
International Reviews of Immunology, 1995Type I collagen, the most abundant protein of the body, is preferentially synthesized in bone, dermis, and tendons by two cell types, the osteoblast and the fibroblast. The expression of type I collagen is increased in the various forms of fibrosis such as lung, liver, bone marrow fibrosis and scleroderma.
G, Karsenty, R W, Park
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Collagen Type I: A Substrate and a Signal for Invasion
2000The phenomenon termed invasion is observed in a large variety of cells and organisms from viruses to vertebrate cells (Leroy et al. 1997). Invasion implicates entry of foreign cells into a host by attachment to the extracellular matrix (ECM) components, proteolysis of these components, and subsequently migration through the ECM defects (Bruyneel and ...
L, Van Hoorde, E, Van Aken, M, Mareel
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