Results 51 to 60 of about 351,215 (306)

A histologic study of the extracellular matrix during the development of glomerulosclerosis in murine chronic graft-versus-host disease. [PDF]

, 1992
The development of glomerulosclerosis was studied in murine chronic graft-versus-host disease (GvHD), which is a model for human systemic lupus erythematosus.
Baelde, J. J., Bergijk, E. C., Brujn, J. A., Foidart, Jean-Michel, Hoedemaeker, P. J., Munaut, Carine, Prins, F.   +6 more
core  

Type III collagen modulates fracture callus bone formation and early remodeling [PDF]

, 2015
Type III collagen (Col3) has been proposed to play a key role in tissue repair based upon its temporospatial expression during the healing process of many tissues, including bone.
Brisson, Becky K., Dopkin, Derek, Gleason, Hadley, Hamilton, Todd, Hankenson, Kurt D., Kozloff, Kenneth M., Lopas, Luke, Miedel, Emily L., Perosky, Joseph E., Swain, Gary P., Volk, Susan W.   +10 more
core   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Growth characteristics in individuals with osteogenesis imperfecta in North America: results from a multicenter study. [PDF]

, 2019
PurposeOsteogenesis imperfecta (OI) predisposes people to recurrent fractures, bone deformities, and short stature. There is a lack of large-scale systematic studies that have investigated growth parameters in OI.MethodsUsing data from the Linked ...
A Lund, A Markmann, AD Letocha, AK Anissipour, Allison Tam, B Sykes, BJ Belt-Niedbala, Brendan Lee, BU Nwosu, C Land, D Gatti, David Cuthbertson, DO Sillence, DR Keene, EL Germain-Lee, ER Barros, F Rauch, F Rauch, FH Glorieux, Francis H. Glorieux, Frank Rauch, I Grafe, Jay R. Shapiro, JC Marini, JC Marini, JD Hald, Jeff Krischer, JM Tanner, K Graff, L Zeitlin, LA Dimeglio, Mahim Jain, Mary Mullins, Melanie Pepin, MG Seikaly, Michael B. Bober, Michaela Durigova, MS Aglan, N Bishop, N Bishop, Peter A. Smith, Peter H. Byers, R Sakkers, RH Engelbert, RH Engelbert, RM Patel, Robert D. Steiner, RT Hamza, S Bellur, Sandesh C. S. Nagamani, Sunil Bellur, T Palomo, T Yang, Tracy Hart, U Vetter, V. Reid Sutton, Y Takeuchi   +56 more
core   +2 more sources

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Collagen Expression in Various Degenerative Meniscal Changes: An Immunohistological Study

Journal of Orthopaedic Surgery, 2013
Purpose. To examine changes in acid mucopolysaccharides and collagen expression during meniscal degeneration, tearing, and repair, using menisci excised from knee joint surgeries. Methods.
Takatomo Mine, Koichiro Ihara, Hiroyuki Kawamura, Ryo Date, Keitaro Umehara   +4 more
doaj   +1 more source

Collagenofibrotic Glomerulopathy with Thrombotic Microangiopathy: A Rare Case Report [PDF]

Journal of Clinical and Diagnostic Research
Collagenofibrotic Glomerulopathy (CG) is a very rare glomerular disease characterised by the massive accumulation of atypical type III collagen fibrils within the mesangial matrix and subendothelial space, as well as a marked increase in serum type III ...
Khushbu Agarwal, Kamal Kanodia, Shreya Solanki, Rashmi Patel, Kamlesh Suthar   +4 more
doaj   +1 more source

Fibrotic and Vascular Remodelling of Colonic Wall in Patients with Active Ulcerative Colitis [PDF]

, 2016
open16noIntestinal fibrosis is a complication of inflammatory bowel disease [IBD]. Although fibrostenosis is a rare event in ulcerative colitis [UC], there is evidence that a fibrotic rearrangement of the colon occurs in the later stages.
Bassotti, Gabrio, Bernardini, Nunzia, Blandizzi, Corrado, Buccianti, Piero, Campani, Daniela, Castagna, Maura, Colucci, Rocchina, Di Candio, Giulio, Dolfi, Amelio, ERREDE, Mariella, GIROLAMO, FRANCESCO, Ippolito, Chiara, Segnani, Cristina, Tirotta, Erika, Villanacci, Vincenzo, VIRGINTINO, Daniela   +15 more
core   +2 more sources

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Chemical chaperone treatment reduces intracellular accumulation of mutant collagen IV and ameliorates the cellular phenotype of a COL4A2 mutation that causes haemorrhagic stroke [PDF]

, 2013
Haemorrhagic stroke accounts for approximately 20% of stroke cases and porencephaly is a clinical consequence of perinatal cerebral haemorrhaging. Here we report the identification of a novel dominant G702D mutation in the collagen domain of COL4A2 ...
Aislynn Taggart, Bateman, Brazel, Catheline Vilain, de Clerck, Engin, Favor, Geesin, Gould, Gould, Gould, Hostikka, Ishida, Jeanne, Kalluri, Karl E. Kadler, Khoshnoodi, Lydia S. Murray, Marc Abramowicz, Muthukumaran, Nicole Van Regemorter, Ozcan, Plaisier, Plaisier, Poschl, Ron, Taylor, Tom Van Agtmael, Vahedi, Van Agtmael, Van Agtmael, Van Agtmael, Verbeek, Vilain, Woo, Yinhui Lu   +35 more
core   +1 more source