Results 51 to 60 of about 45,139 (258)

Macrophage Extracellular Traps in Immunity and Cancer

Advanced Science, EarlyView.
As a macrophage‐mediated innate defense mechanism, the dysregulated release of METs drives chronic inflammation and influences tumor progression. Furthermore, METs exhibit a functional duality within the tumor microenvironment, capable of both promoting and suppressing tumor development.
Junyao Li, Eugenie Nepovimova, Adam Grundel, Lukas Peter, Qinghua Wu, Kamil Kuca   +5 more
wiley   +1 more source

Salient features of the coronary collateral circulation and its clinical relevance

Swiss Medical Weekly, 2015
The coronary collateral circulation provides an alternative source of blood supply to myocardium jeopardised by ischaemia. Collaterals enlarge with obstructive coronary artery disease to allow bulk flow, but blood flow deliverable by the native, pre ...
Michael Stoller, Christian Seiler
doaj   +1 more source

Anemia Predicts Poor Clinical Outcome in Mechanical Thrombectomy Patients with Fair or Good Collateral Circulation

Cerebrovascular Diseases Extra, 2020
Background and Purpose: Anemia predicts poor clinical outcome of ischemic stroke in the general stroke population. We studied whether this applies to those treated with mechanical thrombectomy for proximal anterior circulation occlusion in the setting of
Juha-Pekka Pienimäki, Sara Protto, Eetu Hakomäki, Pasi Jolma, Niko Sillanpää   +4 more
doaj   +1 more source

Nanotherapeutic Macrophage‐Neuro Reprogramming Through Immunometabolic Crosstalk Mitigates Sepsis‐Induced Lung Injury and Neurologic Damage

Advanced Science, EarlyView.
SJNPs co‐deliver JHU083 and spermine to reprogram macrophage–neuron immunometabolic crosstalk in sepsis. By suppressing pro‐inflammatory M1 polarization and promoting NGF‐mediated neurotrophic signaling, SJNPs preserve pulmonary neuronal integrity, alleviate lung injury, and improve survival in murine sepsis models.
Wenhui Wang, Yongrui Hai, Xintong Lu, Ye Chen, Bingjie Zhang, Renming Fan, Jiarui Dou, Jiaxin Yan, Shuo Fu, Wen Zhang, Junke Song, Gaofei Wei   +11 more
wiley   +1 more source

Automated Classification of Collateral Circulation for Ischemic Stroke in Cone-Beam CT Images Using VGG11: A Deep Learning Approach

BioMedInformatics
Background: Ischemic stroke poses significant challenges in diagnosis and treatment, necessitating efficient and accurate methods for assessing collateral circulation, a critical determinant of patient prognosis.
Nur Hasanah Ali, Abdul Rahim Abdullah, Norhashimah Mohd Saad, Ahmad Sobri Muda, Ervina Efzan Mhd Noor   +4 more
doaj   +1 more source

Persistently Increased Expression of PKMzeta and Unbiased Gene Expression Profiles Identify Hippocampal Molecular Traces of a Long‐Term Active Place Avoidance Memory and “Shadow” Proteins

Advanced Science, EarlyView.
Protein complexes like KIBRA‐PKMζ are crucial for maintaining memories, forming month‐long protein traces in memory‐tagged neurons, but conventional RNA‐seq analysis fails to detect their transcript changes, leaving memory molecules undetected in the shadows of abundantly‐expressed genes.
Jiyeon Han, Alejandro Grau‐Perales, Rayna M. Harris, Edith Lesburguères, Hsin‐Yi Kao, Asit Pal, Juan Marcos Alarcon, Todd C. Sacktor, Stefano Martiniani, Hans A. Hofmann, André A. Fenton   +10 more
wiley   +1 more source

脑侧支循环在缺血性卒中的研究进展 Research Progress of Cerebral Collateral Circulation Status in Ischemic Stroke

Zhongguo cuzhong zazhi, 2018
缺血性卒中是我国中老年人主要的致死、致残原因，而侧支循环对缺血性卒中的代偿作 用至关重要。随着影像学技术的发展，侧支循环评估的准确性得到大幅提高，许多大型临床试验也开 始结合侧支循环的评估制定治疗策略。另外，改善侧支循环具有巨大的潜在治疗价值。本文主要围 绕侧支循环在缺血性卒中的研究进展进行综述。 Abstract: Ischemic stroke is the main cause of death and disability in middle aged and elderly ...
张俊芳，张雨蕾，尹肖睿，吴云成
doaj   +1 more source

Nanomedicine Meets Immunotherapy: Advancing Adoptive Cell Therapy with Nanoparticles in the Treatment of Cancer with Sustainability Perspectives

Advanced Science, EarlyView.
This review surveys nanoparticle‐based strategies to enhance adoptive cell therapy, particularly CAR‐T cell approaches, in solid tumor treatment. It describes how nanoparticles can improve tumor immunogenicity and T‐cell infiltration while reducing toxicity, and how they enable in vivo CAR‐T cell generation.
Erica Frostegård, Tatiana Bobrova, Amalie Leinebø, Thibault Leray, Shayamita Ghosh, Lorena García‐Hevia, Chiara Puccinelli, Lorenzo Riccio, Jacopo Sorani, Davide Bonifazi, Julien Caumartin, Emmanuel Donnadieu, Florence Gazeau, Roland Hischier, Else Marit Inderberg, Mónica L. Fanarraga, Maria Loustau, Bernd Nowack, Sébastien Wälchli, Cécilia Ménard‐Moyon   +19 more
wiley   +1 more source

Redox‐Responsive Polymeric Nanocapsules for Enhanced Tumor‐Targeted Delivery of Antimicrobial Peptides

Advanced Science, EarlyView.
This study presents a modular redox‐responsive nanocapsule platform that enables enhanced tumor‐targeted delivery of antimicrobial peptides. Using melittin as an example, the system achieves controlled activation within the tumor microenvironment, improving intratumoral accumulation while minimizing systemic toxicity.
Lin Tang, Yajian Li, Xiaoyin Lv, Jianmei Guo, Yijia Zhang, Yuqi Lin, Kaili Nie, Jian Zeng, Ming Zhang, Qiong Dai   +9 more
wiley   +1 more source

Enhancing the clinical value of single-phase computed tomography angiography in the assessment of collateral circulation in acute ischemic stroke: A narrative review

Brain Circulation
Acute ischemic stroke (AIS) condition assessment and clinical prognosis are significantly influenced by the compensatory state of cerebral collateral circulation.
Yunqiu Yang, Zhen Wang, Qingmao Hu, Libo Liu, Guorui Ma, Chen Yang   +5 more
doaj   +1 more source