Results 121 to 130 of about 7,287,837 (290)

Assessing the feasibility of collective licensing of in-copyright works as training data for generative AI systems. [PDF]

Proc Natl Acad Sci U S A
Samuelson P.
europepmc   +1 more source

[Baldwin Locomotive Works Paris Office Drawing Card, Sketch No. 5487]

, 1910
This engine drawing card was created for Baldwin Locomotive Works Paris office, Class 6-18 1/3 C. Section J-6 1/3 C. Sketch 5487. Copy Spec.
Baldwin Locomotive Works
core  

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

From registration to insight: how STRONG AYA transforms registry data to enhance decision-support tools for adolescent and young adult oncology. [PDF]

ESMO Real World Data Digit Oncol
Hughes NF, Hogenboom J, Carter RN, Norman LJ, Gouthamchand V, Lindner OC, Connearn E, Gomes AL, Sikora-Koperska A, Rosińska M, Pogoda K, Wiechno P, Jagodzińska-Mucha P, Ługowska I, Hanebaum S, Dekker ALAJ, van der Graaf WTA, Husson O, Wee LYL, Feltbower RG, Stark DP.   +20 more
europepmc   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Insects in Classical Music. [PDF]

Insects
Coelho JR.
europepmc   +1 more source

[Carnegie Steel Co. (Bellaire Works), Engine Drawing Card, Sketch No. 6387]

, 1916
This engine drawing card was created for the Carnegie Steel Company, Bellaire Works, Class 4-20C. Section N 4C. Sketch 6387. Copy Spec.
Baldwin Locomotive Works
core  

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Fostering hand disinfections in medical facilities: discussion of ethical conflicts and technical solutions. [PDF]

BMC Med Ethics
Russow F, Cap CH, Põder JC.
europepmc   +1 more source

[Carnegie Steel Co. (Bellaire Works), Engine Drawing Card, Sketch No. 6416]

, 1916
This engine drawing card was created for the Carnegie Steel Company, Bellaire Works, Class 4-20C. Section N 4C. Sketch 6416. Copy Spec.
Baldwin Locomotive Works
core