Results 161 to 170 of about 3,115,714 (294)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Uncovering simultaneous breakthroughs with a robust measure of disruptiveness. [PDF]

Sci Adv
Kim M, Kojaku S, Ahn YY.
europepmc   +1 more source

Zubryts’kyi, Mykhailo. Zibrani tvory i materialy u tr’okh tomakh. Tom 1: Naukovi pratsi. Titlepage in English: Collected Works and Materials. Volume 1: Scholarly Works [PDF]

, 2015
Klymasz, Robert B.
core   +2 more sources

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

From the Past to the Present and towards Possible Futures: The Collected Works of Norbert Elias (Zpráva o konferenci)

Historicka Sociologie, 2014
Jiří Šubrt
doaj   +1 more source

Collected works

, 1921
01. FIRST REPORT OF THE MINE RESCUE APPARATUS RESEARCH COMMITTEE || 02. SECOND REPORT OF THE MINE RESCUE APPARATUS RESEARCH COMMITTEE. || 03. PHYSICAL EXERTION, FITNESS AND BREATHING. || 04. PHYSICAL WORK AND THE HUMAN MACHINE. || 05. THE MILITARY PHYSICAL TEST STATION, EDINBURGH. || 06. PREPARATION and PROPERTIES of HIGHLY ACTIVATED
openaire   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Health insurance and the distribution of healthcare use in Rwanda's Vision Umurenge Programme: evidence from the Seventh Integrated Household Living Conditions Survey. [PDF]

Glob Health Action
de Dieu Harerimana J.
europepmc   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Glowing Spicules and Structural Collapse: A Single-Cell Insight into the Oxidative Aging of Favism Erythrocytes. [PDF]

Int J Mol Sci
Longo G, Dinarelli S, Girasole M.
europepmc   +1 more source